The structural basis for interhemispheric functional connectivity: Evidence from individuals with agenesis of the corpus callosum.
The structural basis for interhemispheric functional connectivity: Evidence from individuals with agenesis of the corpus callosum.
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DOI：
10.1016/j.nicl.2020.102425
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Du F
中科院分区：
文献类型：
--
作者：
Yuan J;Song X;Kuan E;Wang S;Zuo L;Ongur D;Hu W;Du F
AgCC整体结构受损，但功能网络性质完好。AgCC显示半球内结构连通性增强。AgCC显示半球间同位FC明显减少。VMHC与穿越CC的纤维数量和质量相关，纤维连接较多的脑区倾向于相互建立较高的FC。胼胝体发育不全（AgCC）是一种罕见的先天性畸形，其特征是胼胝体部分或完全缺失（CC）。AgCC对大脑结构和功能网络的影响尚不清楚。我们的目的是利用AgCC作为一个模型来表征大脑结构和功能之间的关系。收集9例AgCC和10例健康受试者的扩散张量成像和静息状态fMRI数据。采用体素镜像同伦连通性（VMHC）方法量化了脑半球间功能连通性（FC），并计算了其与穿过CC的纤维数目（FN）和分数各向异性（FA）的相关性。基于图的网络分析了结构和功能拓扑特性。与对照组相比，AgCC受试者的VMHC明显降低。VMHC与穿过CC的纤维的FN和FA显著相关。结构网络分析显示，与对照组相比，AgCC的整体特性受损，但局部特性完好。功能网络分析显示，两组之间的网络特性无显著差异。最后，在两组中，纤维连接较多的大脑区域更有可能相互形成正FC，而白质连接较少的区域更有可能形成负FC。我们的观察表明，半球间FC高度依赖于CC结构。增加的选择性半球内SC可能是AgCC的代偿机制，有助于维持正常的整体脑功能。我们的研究提供了对脑畸形的潜在神经病理生理学的见解，从而有助于阐明正常人脑的结构-功能关系。
AgCC showed impaired global structural, but intact functional network properties. AgCC showed increased intrahemispheric structural connectivity. AgCC showed markedly reduced interhemispheric homotopic FC. The VMHC was correlated with the number and quality of fibers crossing the CC. Brain areas with more fiber connections tended to build higher FC with each other. Agenesis of the corpus callosum (AgCC) is a rare congenital malformation characterized by partial or complete absence of the corpus callosum (CC). The effects of AgCC on cerebral structural and functional networks are not clear. We aimed to utilize AgCC as a model to characterize the relationship between brain structure and function. Diffusion tensor imaging and resting-state fMRI data were collected from nine AgCC and ten healthy subjects. The interhemispheric functional connectivity (FC) was quantified using a voxel-mirrored-homotopic-connectivity (VMHC) method, and its correlation with the number (FN) and fractional anisotropy (FA) of the fibers crossing the CC was calculated. Graph-based network analyses of structural and functional topologic properties were performed. AgCC subjects showed markedly reduced VMHC compared to controls. VMHC was significantly correlated with the FN and FA of the fibers crossing the CC. Structural network analyses revealed impaired global properties, but intact local properties in AgCC compared to controls. Functional network analyses showed no significant difference in network properties between the groups. Finally, in both groups, brain areas with more fiber connections were more likely to build a positive FC with each other, while areas with decreased white matter connections were more likely to result in negative FC. Our observations demonstrate that interhemispheric FC is highly dependent on CC structure. Increased alternative intrahemispheric SC might be a compensatory mechanism in AgCC that helps to maintain normal global brain function. Our study provides insights into the underlying neurological pathophysiology of brain malformations, thereby helping to elucidate the structure–function relationship of normal human brain.
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影响因子：
3.7
作者：
Song XW;Dong ZY;Long XY;Li SF;Zuo XN;Zhu CZ;He Y;Yan CG;Zang YF
通讯作者：
Zang YF
影响因子：
--
作者：
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通讯作者：
Miguel-Hidalgo JJ
影响因子：
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作者：
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通讯作者：
Langs, Georg
影响因子：
3.4
作者：
Meier, Jil;Tewarie, Prejaas;Van Mieghem, Piet
通讯作者：
Van Mieghem, Piet
影响因子：
4.6
作者：
Mancuso, Lorenzo;Costa, Tommaso;Cauda, Franco
通讯作者：
Cauda, Franco