Fine-scale variation in vector host use and force of infection drive localized patterns of West Nile virus transmission.
Fine-scale variation in vector host use and force of infection drive localized patterns of West Nile virus transmission.
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DOI：
10.1371/journal.pone.0023767
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Goldberg TL
中科院分区：
文献类型：
--
作者：
Hamer GL;Chaves LF;Anderson TK;Kitron UD;Brawn JD;Ruiz MO;Loss SR;Walker ED;Goldberg TL
宿主多样性对多宿主病原体传播和持久性的影响可能会被大量的物种和生物相互作用所混淆，这些物种和生物相互作用可以表征许多传播系统。对于病媒传播的病原体，假设宿主群落的组成会影响传播;然而，影响传播的宿主群落的具体特征在很大程度上仍然未知。我们检验了载体宿主使用和感染力（即，在宿主群落中以每种脊椎动物宿主为食而产生的感染性蚊子的总数），而不仅仅是宿主多样性或丰富性，决定了蚊子媒介中西尼罗河病毒（WNV）的局部感染率。在美国伊利诺斯州的芝加哥郊区，我们使用库蚊蚊子宿主选择和WNV脊椎动物储库能力的数据，在多个住宅和半自然研究地点的每种宿主物种估计西尼罗河病毒的社区感染力。我们发现宿主群落感染力与鸟类多样性相互作用，影响整个研究区域库蚊感染西尼罗河病毒。两种鸟类，美国知更鸟（Turdus migratorius）和家雀（Passer migratoricus），产生了95.8%的传染性Cx。库蚊感染西尼罗河病毒与西尼罗河病毒感染呈显著正相关。蚊子因此，群落结构的指标，如物种多样性或丰富度，可能不是可靠的指标，在精细的空间尺度上的传播媒介传播的疾病系统的风险。相反，当地传播风险的强有力的评估应纳入媒介宿主喂养的异质性和在空间尺度上的媒介-宿主相互作用的脊椎动物水库能力的变化。
The influence of host diversity on multi-host pathogen transmission and persistence can be confounded by the large number of species and biological interactions that can characterize many transmission systems. For vector-borne pathogens, the composition of host communities has been hypothesized to affect transmission; however, the specific characteristics of host communities that affect transmission remain largely unknown. We tested the hypothesis that vector host use and force of infection (i.e., the summed number of infectious mosquitoes resulting from feeding upon each vertebrate host within a community of hosts), and not simply host diversity or richness, determine local infection rates of West Nile virus (WNV) in mosquito vectors. In suburban Chicago, Illinois, USA, we estimated community force of infection for West Nile virus using data on Culex pipiens mosquito host selection and WNV vertebrate reservoir competence for each host species in multiple residential and semi-natural study sites. We found host community force of infection interacted with avian diversity to influence WNV infection in Culex mosquitoes across the study area. Two avian species, the American robin (Turdus migratorius) and the house sparrow (Passer domesticus), produced 95.8% of the infectious Cx. pipiens mosquitoes and showed a significant positive association with WNV infection in Culex spp. mosquitoes. Therefore, indices of community structure, such as species diversity or richness, may not be reliable indicators of transmission risk at fine spatial scales in vector-borne disease systems. Rather, robust assessment of local transmission risk should incorporate heterogeneity in vector host feeding and variation in vertebrate reservoir competence at the spatial scale of vector-host interaction.
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影响因子：
8.8
作者：
Anderson, RA;Roitberg, BD
通讯作者：
Roitberg, BD
影响因子：
64.8
作者：
Keesing F;Belden LK;Daszak P;Dobson A;Harvell CD;Holt RD;Hudson P;Jolles A;Jones KE;Mitchell CE;Myers SS;Bogich T;Ostfeld RS
通讯作者：
Ostfeld RS
影响因子：
2.9
作者：
Dobson, A
通讯作者：
Dobson, A
DOI：
10.1016/0035-9203(86)90199-9
发表时间：
1986-01-01
影响因子：
2.2
作者：
DYE, C;HASIBEDER, G
通讯作者：
HASIBEDER, G
影响因子：
11.8
作者：
Eisen, Lars;Eisen, Rebecca J.
通讯作者：
Eisen, Rebecca J.