Laundry detergent promotes allergic skin inflammation and esophageal eosinophilia in mice.
Laundry detergent promotes allergic skin inflammation and esophageal eosinophilia in mice.
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DOI：
10.1371/journal.pone.0268651
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
过敏性疾病的患病率正在上升，但导致这种增加的环境因素仍在阐明。含有包括微生物酶在内的细胞毒性成分的洗衣洗涤剂（LD）从婴儿期开始持续接触皮肤。皮肤屏障受损被认为是过敏性致敏的一种途径。我们假设皮肤暴露于LD会损害皮肤屏障，导致对通过受损皮肤屏障进入的过敏原的全身致敏。体外暴露于微生物蛋白酶或LD的小鼠皮肤样本表现出物理损伤，与成人皮肤相比，新生儿皮肤的损伤更为明显。皮肤暴露于体外微生物蛋白酶导致白细胞介素（IL）-33和胸腺基质淋巴细胞生成素（TSLP）水平的增加。BALB/c野生型小鼠表皮暴露于LD和卵清蛋白（OVA）后，经表皮水分丢失、血清中OVA特异性免疫球蛋白（IG）G1和IgE抗体水平升高，局部IL 33、Tslp、IL 4和IL 13水平升高。经鼻内用OVA激发后，暴露于LD的小鼠上表皮显示与单独的LD或OVA相比，过敏原诱导的食管嗜酸性粒细胞增多。总的来说，这些结果表明，LD可能是一个重要的因素，损害皮肤屏障，并导致过敏原致敏的早期生活，因此可能有一个作用，在过敏性疾病的增加。
The prevalence of allergic diseases is on the rise, yet the environmental factors that contribute to this increase are still being elucidated. Laundry detergent (LD) that contains cytotoxic ingredients including microbial enzymes continuously comes into contact with the skin starting in infancy. An impaired skin barrier has been suggested as a route of allergic sensitization. We hypothesized that exposure of skin to LD damages the skin barrier resulting in systemic sensitization to allergens that enter through the impaired skin barrier. Mouse skin samples exposed in vitro to microbial proteases or LD exhibited physical damage, which was more pronounced in neonatal skin as compared to adult skin. Exposure of the skin to microbial proteases in vitro resulted in an increase in the levels of interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP). BALB/c wild type mice epicutaneously exposed to LD and ovalbumin (OVA) showed an increase in levels of transepidermal water loss, serum OVA-specific immunoglobulin (Ig) G1 and IgE antibodies, and a local increase of Il33, Tslp, Il4 and Il13 compared with LD or OVA alone. Following intranasal challenge with OVA, mice epicutaneously exposed to LD showed an increase in allergen-induced esophageal eosinophilia compared with LD or OVA alone. Collectively, these results suggest that LD may be an important factor that impairs the skin barrier and leads to allergen sensitization in early life, and therefore may have a role in the increase in allergic disease.
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影响因子：
29.4
作者：
Akei, HS;Mishra, A;Rothenberg, ME
通讯作者：
Rothenberg, ME
DOI：
10.1016/j.jaci.2010.10.039
发表时间：
2011-01
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Blanchard C;Stucke EM;Rodriguez-Jimenez B;Burwinkel K;Collins MH;Ahrens A;Alexander ES;Butz BK;Jameson SC;Kaul A;Franciosi JP;Kushner JP;Putnam PE;Abonia JP;Rothenberg ME
通讯作者：
Rothenberg ME
影响因子：
2.9
作者：
Elias, Peter M.;Menon, Gopinathan;Wetzel, Bruce K.;Williams, John (Jack) W.
通讯作者：
Williams, John (Jack) W.
影响因子：
5.5
作者：
Branco, N;Lee, I;Maibach, HI
通讯作者：
Maibach, HI
影响因子：
2.7
作者：
Darlenski, Razvigor;Fluhr, Joachim W.
通讯作者：
Fluhr, Joachim W.