Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis.
Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis.
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DOI：
10.1038/s41598-018-24361-8
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发表时间：
2018-04-18
影响因子：
4.6
通讯作者：
Opsteegh M
中科院分区：
文献类型：
--
作者：
Deng H;Devleesschauwer B;Liu M;Li J;Wu Y;van der Giessen JWB;Opsteegh M
孕妇的原发性弓形虫感染可能导致流产、死产或未出生的孩子终身残疾。人类的主要传播途径之一是食用含有弓形虫组织包囊的生肉或未煮熟的肉。我们的目的是通过系统的文献综述来确定和比较中国孕妇和产肉牲畜中弓形虫血清流行率的区域分布。从 Medline、Scopus、Embase 和中国国家知识基础设施中总共确定了 272 篇符合条件的出版物。使用新颖的贝叶斯分层模型按区域分析表观和真实的血清流行率，该模型允许合并所应用血清学测定的敏感性和特异性。中国七个地区孕妇弓形虫真实血清阳性率为5.0%或更低。猪的区域真实血清流行率中位数（24%）显着高于牛（9.5%），但不显着高于鸡（20%）和小反刍动物（20%）。这项研究首次使用贝叶斯分层模型来获得区域真实血清流行率。这些结果与肉类消费数据相结合，可以用来更好地了解产肉动物对中国人类弓形虫感染的贡献。
Primary Toxoplasma gondii infection in pregnant women may result in abortion, stillbirth, or lifelong disabilities of the unborn child. One of the main transmission routes to humans is consumption of raw or undercooked meat containing T. gondii tissue cysts. We aim to determine and compare the regional distribution of T. gondii seroprevalence in pregnant women and meat-producing livestock in China through a systematic literature review. A total of 272 eligible publications were identified from Medline, Scopus, Embase and China National Knowledge Infrastructure. Apparent and true seroprevalence were analysed by region using a novel Bayesian hierarchical model that allowed incorporating sensitivity and specificity of the applied serological assays. The true seroprevalence of T. gondii in pregnant women was 5.0% or less in seven regions of China. The median of the regional true seroprevalences in pigs (24%) was significantly higher than in cattle (9.5%), but it was not significantly higher than in chickens (20%) and small ruminants (20%). This study represents the first use of a Bayesian hierarchical model to obtain regional true seroprevalence. These results, in combination with meat consumption data, can be used to better understand the contribution of meat-producing animals to human T. gondii infection in China.
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