Single and dual crosslinked oxidized methacrylated alginate/PEG hydrogels for bioadhesive applications.
Single and dual crosslinked oxidized methacrylated alginate/PEG hydrogels for bioadhesive applications.
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DOI：
10.1016/j.actbio.2013.09.004
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发表时间：
2014-01
影响因子：
9.7
通讯作者：
Alsberg, Eben
中科院分区：
文献类型：
--
作者：
Jeon, Oju;Samorezov, Julia E.;Alsberg, Eben
一种可降解的、细胞相容的生物粘合剂可以促进外科手术，并最大限度地减少患者疼痛和术后并发症。在这项研究中，一个生物粘附性水凝胶系统的基础上氧化，甲基丙烯酸化海藻酸盐/8臂聚（乙二醇）胺（OMA/PEG）已开发，和交联的OMA/PEG水凝胶的生物粘附特性进行了评估。在这里，我们证明了交联的OMA/PEG水凝胶的溶胀行为，降解曲线和储能模量是可调的，通过改变海藻酸盐的氧化程度。交联的OMA/PEG水凝胶在与人骨髓间充质干细胞培养时表现出细胞相容性。此外，这些水凝胶的粘附强度，通过改变藻酸盐氧化水平和使用猪皮模型测量的可控，上级市售的纤维蛋白胶。该OMA/PEG水凝胶系统具有可控的生物降解性和机械性能以及粘附强度，可能是一种有前途的生物粘合剂，用于临床生物医学应用，如药物递送、伤口闭合和愈合、生物医学装置植入和组织工程。
A degradable, cytocompatible bioadhesive can facilitate surgical procedures and minimize patient pain and postsurgical complications. In this study, a bioadhesive hydrogel system based on oxidized, methacrylated alginate/8-arm poly(ethylene glycol) amine (OMA/PEG) has been developed, and the bioadhesive characteristics of the crosslinked OMA/PEG hydrogels are evaluated. Here, we demonstrate that the swelling behavior, degradation profiles, and storage moduli of crosslinked OMA/PEG hydrogels are tunable by varying the degree of alginate oxidation. The crosslinked OMA/PEG hydrogels exhibit cytocompatibility when cultured with human bone marrow-derived mesenchymal stem cells. In addition, the adhesion strength of these hydrogels, controllable by varying the alginate oxidation level and measured using a porcine skin model, is superior to commercially available fibrin glue. This OMA/PEG hydrogel system with controllable biodegradation and mechanical properties and adhesion strength may be a promising bioadhesive for clinical use in biomedical applications, such as drug delivery, wound closure and healing, biomedical device implantation, and tissue engineering.
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