Understanding Nanoparticle Toxicity to Direct a Safe-by-Design Approach in Cancer Nanomedicine.
Understanding Nanoparticle Toxicity to Direct a Safe-by-Design Approach in Cancer Nanomedicine.
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DOI：
10.3390/nano10112186
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发表时间：
2020-11-02
期刊：
影响因子：
--
通讯作者：
Melancon MP
中科院分区：
文献类型：
--
作者：
Damasco JA;Ravi S;Perez JD;Hagaman DE;Melancon MP
纳米医学是一个快速发展的领域，使用纳米材料诊断，治疗和预防各种疾病，包括癌症。具有肿瘤靶向、成像和治疗的多样化能力的各种生物相容性纳米平台已经实现，以产生个体化治疗。然而，由于其小尺寸所带来的独特性质，安全性问题已经出现，因为其理化性质可能导致药代动力学改变，并有可能跨越生物屏障。此外，某些无机材料的固有毒性（即，重金属）以及它们在人体内积累和持久存在的能力对它们的转化是一个挑战。这些纳米颗粒的成功临床转化在很大程度上取决于它们的稳定性、循环时间、对疾病部位的可及性和生物利用度以及它们的安全性。这篇综述涵盖了用于癌症成像和治疗的临床前和临床无机纳米颗粒基纳米材料。一个特别强调的是合理的设计，开发无毒/安全的无机纳米粒子结构，以增加其作为癌症治疗的可翻译纳米药物的可行性。
Nanomedicine is a rapidly growing field that uses nanomaterials for the diagnosis, treatment and prevention of various diseases, including cancer. Various biocompatible nanoplatforms with diversified capabilities for tumor targeting, imaging, and therapy have materialized to yield individualized therapy. However, due to their unique properties brought about by their small size, safety concerns have emerged as their physicochemical properties can lead to altered pharmacokinetics, with the potential to cross biological barriers. In addition, the intrinsic toxicity of some of the inorganic materials (i.e., heavy metals) and their ability to accumulate and persist in the human body has been a challenge to their translation. Successful clinical translation of these nanoparticles is heavily dependent on their stability, circulation time, access and bioavailability to disease sites, and their safety profile. This review covers preclinical and clinical inorganic-nanoparticle based nanomaterial utilized for cancer imaging and therapeutics. A special emphasis is put on the rational design to develop non-toxic/safe inorganic nanoparticle constructs to increase their viability as translatable nanomedicine for cancer therapies.
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影响因子：
5.6
作者：
Ashton JR;West JL;Badea CT
通讯作者：
Badea CT
影响因子：
17.1
作者：
Bouwmeester, Hans;Poortman, Jenneke;Hendriksen, Peter J. M.
通讯作者：
Hendriksen, Peter J. M.
影响因子：
3.2
作者：
Avalos, Alicia;Isabel Haza, Ana;Morales, Paloma
通讯作者：
Morales, Paloma
影响因子：
5.9
作者：
Bawa, Raj;Johnson, Summer
通讯作者：
Johnson, Summer
DOI：
10.1007/978-3-540-29355-2_2
发表时间：
2008
期刊：
Magnetic Resonance Tomography
影响因子：
--
作者：
Brix G;Kolem H;Nitz WR;Bock M;Huppertz A;Zech CJ;Dietrich O
通讯作者：
Dietrich O