Quench the thirst: lessons from clinical thirst trials.
Quench the thirst: lessons from clinical thirst trials.
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DOI：
10.1177/1099800413505900
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发表时间：
2014-10
影响因子：
2.5
通讯作者：
Puntillo KA
中科院分区：
文献类型：
--
作者：
Arai SR;Butzlaff A;Stotts NA;Puntillo KA
口渴作为一种症状，一直被认为是医疗机构中最普遍的临床主诉。然而，很少有研究人员通过其与生理因素的相关性来研究口渴。本综述旨在研究口渴等级与介导其主要生理相关因素：血浆渗透压（pOsm）和精氨酸抗利尿素肽（AVP）之间的关系。我们进行了文献检索，以确定人类受试者的临床研究，这些研究调查了口渴与特定生理性口渴相关因子和相关口渴介质的关系。这17项研究回顾了通过高渗透压输注、水剥夺或运动减肥方案引起的口渴。他们证实了完整的渗透性口渴驱动表现为口渴等级和血清pOsm水平上升之间的正线性关系。然而，随血浆渗透压升高而出现的正常代偿性AVP升高有所不同。AVP反应的改变通过暴露于寒冷、物理预处理和水浸泡试验来改变。值得注意的是，老年人的口渴程度有所下降。弱相关性表明血管紧张素II可能在口渴调解中只起次要作用。房利钠激素对口渴的抑制作用不一致。老年人由于感觉缺陷以及无法纠正体积损失而发生深度脱水的风险更高。临床口渴试验表明，血清pOsm值与患者的口渴评分高度相关，但老年人除外。
Thirst, as a symptom, has long been considered the most prevalent clinical complaint patients voice in healthcare settings. Yet, rarely have researchers examined thirst by its correlation with physiologic factors. This review was undertaken to examine the relationships between thirst ratings and factors mediating its primary physiologic correlates: plasma osmolality (pOsm) and arginine vasopressin peptide (AVP). A literature search was undertaken to identify clinical studies in human subjects that investigated the relationship of thirst to specific physiologic thirst-related correlates and associated thirst mediators. The 17 studies reviewed induced thirst by hyperosmolar infusion, through water deprivation or exercise weight-loss regimens. They confirmed intact osmotic thirst drives demonstrated by positive linear relationships between thirst ratings and rising serum pOsm levels. However, the normal compensatory rises in AVP levels that followed the rises in plasma osmolality varied. Alterations in AVP response were modified by exposure to cold, physical pre-conditioning and water immersion tests. Notably, older adults reported diminished thirst ratings. Weak correlations suggest that angiotensin II may play only a minor role in thirst mediation. Atrial natriuretic hormone’s inhibitory effect on thirst was inconsistent. Older adults are at higher risk for profound dehydration due to sensory deficits along with failure to correct volume losses. Clinical thirst trials demonstrated that serum pOsm values were highly correlated with patients’ thirst ratings, with the exception of the older adult.
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DOI：
10.1007/bf03339616
发表时间：
1997-10-01
期刊：
AGING-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
ONeill, PA;Duggan, J;Davies, I
通讯作者：
Davies, I
影响因子：
--
作者：
PHILLIPS, PA;ROLLS, BJ;MORTON, JJ
通讯作者：
MORTON, JJ
DOI：
10.1249/01.mss.0000139901.63911.75
发表时间：
2004-09-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Kenefick, RW;Hazzard, MP;Castellani, JW
通讯作者：
Castellani, JW
影响因子：
4.2
作者：
MARTINEZVEA, A;GARCIA, C;OLIVER, JA
通讯作者：
OLIVER, JA
影响因子：
--
作者：
PHILLIPS, PA;BRETHERTON, M;GRAY, L
通讯作者：
GRAY, L