Loneliness and type 2 diabetes incidence: findings from the English Longitudinal Study of Ageing.
Loneliness and type 2 diabetes incidence: findings from the English Longitudinal Study of Ageing.
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DOI：
10.1007/s00125-020-05258-6
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发表时间：
2020-11
期刊：
影响因子：
8.2
通讯作者：
Chilcot J
中科院分区：
文献类型：
--
作者：
Hackett RA;Hudson JL;Chilcot J
孤独症与全因死亡率和冠心病有关。然而，孤独和2型糖尿病发病之间的前瞻性关系尚不清楚。我们进行了一项纵向观察性人群研究，数据来自英国老龄化纵向研究的4112名无糖尿病参与者（平均年龄65.02 ± 9.05）。2004-2005年使用修订的加州大学洛杉矶分校（UCLA）孤独量表评估孤独。对2006年至2017年发生的2型糖尿病病例进行了评估。相关性采用考克斯比例风险回归建模，调整潜在混杂因素，包括心脏代谢合并症。在随访期间，共有264名（6.42%）参与者发展为2型糖尿病。孤独症是2型糖尿病发病的重要预测因子（HR 1.46; 95% CI 1.15，1.84; p = 0.002），与年龄、性别、种族、财富、吸烟状况、体力活动、饮酒、BMI、HbA 1c、高血压和心血管疾病无关。进一步分析发现孤独与2型糖尿病发病之间存在关联（HR 1.41; 95% CI 1.04，1.90; p = 0.027），独立于抑郁症状、独居和社会隔离。独居和社会隔离与2型糖尿病发病无显著相关性。2型糖尿病的危险因素有哪些？这种关系的机制仍有待阐明。本文的在线版本（10.1007/s 00125 -020-05258-6）包含同行评审但未经编辑的补充材料，可供授权用户使用。
Loneliness is associated with all-cause mortality and coronary heart disease. However, the prospective relationship between loneliness and type 2 diabetes onset is unclear. We conducted a longitudinal observational population study with data on 4112 diabetes-free participants (mean age 65.02 ± 9.05) from the English Longitudinal Study of Ageing. Loneliness was assessed in 2004–2005 using the revised University of California, Los Angeles (UCLA) Loneliness Scale. Incident type 2 diabetes cases were assessed from 2006 to 2017. Associations were modelled using Cox proportional hazards regression, adjusting for potential confounders, which included cardiometabolic comorbidities. A total of 264 (6.42%) participants developed type 2 diabetes over the follow-up period. Loneliness was a significant predictor of incident type 2 diabetes (HR 1.46; 95% CI 1.15, 1.84; p = 0.002) independent of age, sex, ethnicity, wealth, smoking status, physical activity, alcohol consumption, BMI, HbA1c, hypertension and cardiovascular disease. Further analyses detected an association between loneliness and type 2 diabetes onset (HR 1.41; 95% CI 1.04, 1.90; p = 0.027), independent of depressive symptoms, living alone and social isolation. Living alone and social isolation were not significantly associated with type 2 diabetes onset. Loneliness is a risk factor for type 2 diabetes. The mechanisms underlying this relationship remain to be elucidated. Graphical abstract The online version of this article (10.1007/s00125-020-05258-6) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
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DOI：
10.1177/1088868310377394
发表时间：
2011-08
期刊：
Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc
影响因子：
--
作者：
Masi CM;Chen HY;Hawkley LC;Cacioppo JT
通讯作者：
Cacioppo JT
影响因子：
5.1
作者：
Hilding, Agneta;Shen, Chong;Ostenson, Claes-Goran
通讯作者：
Ostenson, Claes-Goran
影响因子：
5
作者：
Haapanen, N;Miilunpalo, S;Vuori, I
通讯作者：
Vuori, I
影响因子：
4
作者：
O'Luanaigh, C.;O'Connell, H.;Lawlor, B. A.
通讯作者：
Lawlor, B. A.
影响因子：
4.7
作者：
Poole, Lydia;Steptoe, Andrew
通讯作者：
Steptoe, Andrew