Two-week treatment with the selective serotonin reuptake inhibitor citalopram reduces contextual anxiety but not cued fear in healthy volunteers: a fear-potentiated startle study.
Two-week treatment with the selective serotonin reuptake inhibitor citalopram reduces contextual anxiety but not cued fear in healthy volunteers: a fear-potentiated startle study.
复制标题
DOI：
10.1038/npp.2008.141
复制
发表时间：
2009-03
影响因子：
7.6
通讯作者：
Pine, Daniel S.
中科院分区：
文献类型：
--
作者：
Grillon, Christian;Chavis, Chanen;Covington, Matthew F.;Pine, Daniel S.
5-羟色胺再摄取抑制剂（SSRIs）长期治疗可缓解焦虑患者的焦虑症状和相关的生理障碍。然而，有限的研究认为，慢性SSRI治疗影响健康个体焦虑的程度。本研究检测了2周西酞普兰治疗对两种威胁反应的影响：短期和长期强化惊吓。先前的工作表明，这两种反应分别在啮齿动物中提供了神经和功能上不同的恐惧和焦虑模型。健康志愿者（n=53）在双盲条件下接受安慰剂或西酞普兰（20 mg/天）两周。每个人在治疗前和治疗后都接受了两次测试。参与者暴露在三种条件下，其中一种是通过暗示发出可预测的厌恶性电击信号，第二种是预期不可预测的电击，第三种是没有电击。厌恶的状态被索引的声学惊吓。研究了在可预测和不可预测条件下，对威胁线索的阶段性恐惧增强惊吓以及对实验情境的持续性惊吓增强。西酞普兰既不影响基线惊吓，也不影响短期恐惧增强惊吓离散威胁线索。然而，西酞普兰减少了可预测条件下的长时间惊吓增强。这些结果与短持续时间和长持续时间的厌恶状态是由不同的神经系统介导的假设是一致的。他们认为，西酞普兰通过作用于长期厌恶状态的潜在机制来减轻预期焦虑的症状，而不是恐惧。
Chronic treatment with serotonin reuptake inhibitors (SSRIs) alleviates both anxiety symptoms and associated physiologic disturbances in anxious patients. However, limited research considers the degree to which chronic SSRI treatment influences anxiety in healthy individuals. This study examined the effect of 2-week citalopram treatment on two threat responses: short- and long-duration potentiated startle. Prior work suggests that these two responses provide neurally and functionally distinct models of fear and anxiety, respectively, in rodents. Healthy volunteers (n=53) received either placebo or citalopram (20 mg/day) for two weeks under double-blind conditions. They were each tested twice, before and after treatment. Participants were exposed to three conditions including one in which predictable aversive shocks were signaled by a cue, a second in which unpredictable shocks were anticipated, and a third in which no shocks were administered. Aversive states were indexed by acoustic startle. Phasic fear-potentiated startle to the threat cue as well as sustained startle potentiation to the experimental context in the predictable and unpredictable conditions were investigated. Citalopram affected neither baseline startle nor short-duration fear-potentiated startle to discrete threat cues. However, citalopram reduced long-duration startle potentiation in the predictable conditions. These results are consistent with the hypothesis that short- and long-duration aversive states are mediated by distinct neural systems. They suggest that citalopram alleviates symptoms of anticipatory anxiety, not fear, by acting on mechanisms underlying long-duration aversive states.
登录
查看更多内容
影响因子：
5.7
作者：
Kemp, AH;Gray, MA;Nathan, PJ
通讯作者：
Nathan, PJ
影响因子：
5.6
作者：
Nutt, DJ;Forshall, S;Argyropoulos, S
通讯作者：
Argyropoulos, S
影响因子：
5.3
作者：
Otto, Tim;Poon, Patrick
通讯作者：
Poon, Patrick
DOI：
10.1073/pnas.95.18.10734
发表时间：
1998-09-01
影响因子：
11.1
作者：
Parks, CL;Robinson, PS;Toth, M
通讯作者：
Toth, M
影响因子：
10.6
作者：
Burghardt, NS;Sullivan, GM;LeDoux, JE
通讯作者：
LeDoux, JE