The development of brain white matter microstructure.
The development of brain white matter microstructure.
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DOI：
10.1016/j.neuroimage.2017.12.097
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发表时间：
2018-11-15
期刊：
影响因子：
5.7
通讯作者：
Deoni S
中科院分区：
文献类型：
--
作者：
Lebel C;Deoni S
在婴儿期、儿童期和青春期，我们的大脑经历了显著的变化。包括髓鞘形成和突触发生在内的过程在生命的前2-3年迅速发生，并且持续的脑重塑持续到成年早期。研究试图描述大脑结构发育的模式，早期的研究主要依赖于大脑结构、形态和组织的大体解剖测量。MRI提供了表征和量化脑组织的一系列微观结构方面的能力，这些方面可能与基本的神经发育过程更密切相关。诸如扩散、磁化传递、弛豫测量和髓磷脂水成像等技术提供了对改变细胞和骨髓结构、神经元密度和结构连接的深入了解。在这篇综述中，我们专注于越来越多的文献，利用这些MRI技术，以更好地了解在成熟过程中发生在大脑白色物质的微观结构变化。我们的评论集中在从出生到成年早期（~25岁）的正常大脑发育的研究，并特别强调纵向研究和更新的技术，被用来研究微观结构的白色物质的发展。所有成像方法均显示在出生后的前3年内一致、快速的显微结构白色物质发育，表明髓鞘形成和轴突堆积增加。弥散研究清楚地表明，在儿童期和青春期后期，白色物质持续成熟，尽管在其他模式中缺乏一致的发现，表明变化可能主要是由于轴突包装。一个新兴的文献详细介绍了男孩和女孩的微结构发展差异，并将发展轨迹与认知能力，行为和/或环境因素联系起来，尽管这些关系的性质尚不清楚。未来的研究将需要集中在更新的成像技术和纵向研究，以提供更详细的信息，微观结构的白色物质的发展，特别是在儿童时期。
Throughout infancy, childhood, and adolescence, our brains undergo remarkable changes. Processes including myelination and synaptogenesis occur rapidly across the first 2–3 years of life, and ongoing brain remodeling continues into young adulthood. Studies have sought to characterize the patterns of structural brain development, and early studies predominately relied upon gross anatomical measures of brain structure, morphology, and organization. MRI offers the ability to characterize and quantify a range of microstructural aspects of brain tissue that may be more closely related to fundamental neurodevelopmental processes. Techniques such as diffusion, magnetization transfer, relaxometry, and myelin water imaging provide insight into changing cyto- and myeloarchitecture, neuronal density, and structural connectivity. In this review, we focus on the growing body of literature exploiting these MRI techniques to better understand the microstructural changes that occur in brain white matter during maturation. Our review focuses on studies of normative brain development from birth to early adulthood (~25 years), and places particular emphasis on longitudinal studies and newer techniques that are being used to study microstructural white matter development. All imaging methods demonstrate consistent, rapid microstructural white matter development over the first 3 years of life, suggesting increased myelination and axonal packing. Diffusion studies clearly demonstrate continued white matter maturation during later childhood and adolescence, though the lack of consistent findings in other modalities suggests changes may be mainly due to axonal packing. An emerging literature details differential microstructural development in boys and girls, and connects developmental trajectories to cognitive abilities, behavior, and/or environmental factors, though the nature of these relationships remains unclear. Future research will need to focus on newer imaging techniques and longitudinal studies to provide more detailed information about microstructural white matter development, particularly in the childhood years.
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DOI：
10.1016/j.nicl.2017.09.026
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Bouziane C;Caan MWA;Tamminga HGH;Schrantee A;Bottelier MA;de Ruiter MB;Kooij SJJ;Reneman L
通讯作者：
Reneman L
影响因子：
3.7
作者：
Blumenfeld-Katzir T;Pasternak O;Dagan M;Assaf Y
通讯作者：
Assaf Y
影响因子：
3.6
作者：
de Bie, Henrica M. A.;Boersma, Maria;Wattjes, Mike P.;Adriaanse, Sofie;Vermeulen, R. Jeroen;Oostrom, Kim J.;Huisman, Jaap;Veltman, Dick J.;Delemarre-Van de Waal, Henriette A.
通讯作者：
Delemarre-Van de Waal, Henriette A.
影响因子：
26.1
作者：
Bick, Johanna;Zhu, Tong;Stamoulis, Catherine;Fox, Nathan A.;Zeanah, Charles;Nelson, Charles A.
通讯作者：
Nelson, Charles A.
影响因子：
5.7
作者：
Chiang MC;McMahon KL;de Zubicaray GI;Martin NG;Hickie I;Toga AW;Wright MJ;Thompson PM
通讯作者：
Thompson PM