Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29.
Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29.
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DOI：
10.1016/j.neuroimage.2010.10.015
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发表时间：
2011-02-01
期刊：
影响因子：
5.7
通讯作者：
Thompson PM
中科院分区：
文献类型：
--
作者：
Chiang MC;McMahon KL;de Zubicaray GI;Martin NG;Hickie I;Toga AW;Wright MJ;Thompson PM
白色物质的微观结构受到强烈的遗传控制，但遗传影响如何从童年到成年的变化在很大程度上是未知的。在有史以来规模最大的一项大脑图谱研究中，我们确定了对白色物质结构的遗传控制是否取决于年龄、性别、社会经济地位（SES）和智商（IQ）。我们评估了白色物质的完整性体素使用扩散张量成像在高磁场（4特斯拉），在705双胞胎及其兄弟姐妹（年龄范围12-29; 290 M/415 F）。白色物质的完整性使用广泛接受的措施，分数各向异性（FA）进行量化。我们逐点拟合基因-环境相互作用模型，以可视化年龄，性别，SES和IQ调节纤维完整性遗传性的大脑区域。我们假设，在儿童晚期和青春期，环境因素开始超过遗传因素。遗传的影响在青春期比成年期更大，男性比女性更大。社会经济地位显着相互作用的基因，影响纤维完整性：遗传力较高的SES。在智商高于平均水平的人群中，遗传因素解释了在丘脑、丘脑、后内囊和上级放射冠中观察到的FA变异性的800%以上。然而，在那些智商低于平均水平的人中，同一地区只有大约40%的FA变异可归因于遗传因素。基因影响纤维完整性，但其影响因年龄、性别、社会经济地位和智商而异。在寻找影响大脑完整性和连通性的特定遗传多态性时，基因-环境相互作用是至关重要的。
White matter microstructure is under strong genetic control, yet it is largely unknown how genetic influences change from childhood into adulthood. In one of the largest brain mapping studies ever performed, we determined whether the genetic control over white matter architecture depends on age, sex, socioeconomic status (SES), and intelligence quotient (IQ). We assessed white matter integrity voxelwise using diffusion tensor imaging at high magnetic field (4-Tesla), in 705 twins and their siblings (age range 12–29; 290 M/415 F). White matter integrity was quantified using a widely accepted measure, fractional anisotropy (FA). We fitted gene-environment interaction models pointwise, to visualize brain regions where age, sex, SES and IQ modulate heritability of fiber integrity. We hypothesized that environmental factors would start to outweigh genetic factors during late childhood and adolescence. Genetic influences were greater in adolescence versus adulthood, and greater in males than in females. Socioeconomic status significantly interacted with genes that affect fiber integrity: heritability was higher in those with higher SES. In people with above-average IQ, genetic factors explained over 800% of the observed FA variability in the thalamus, genu, posterior internal capsule, and superior corona radiata. In those with below-average IQ, however, only around 40% FA variability in the same regions was attributable to genetic factors. Genes affect fiber integrity, but their effects vary with age, sex, SES and IQ. Gene-environment interactions are vital to consider in the search for specific genetic polymorphisms that affect brain integrity and connectivity.
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影响因子：
3.6
作者：
Absil, P;Pinxten, R;Eens, M
通讯作者：
Eens, M
影响因子：
5.8
作者：
Hulshoff Pol, Hilleke E.;Cohen-Kettenis, Peggy T.;Kahn, Rene S.
通讯作者：
Kahn, Rene S.
影响因子：
--
作者：
Bartzokis, G;Beckson, M;Mintz, J
通讯作者：
Mintz, J
DOI：
10.1016/j.jmr.2011.09.022
发表时间：
1996-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Basser, PJ;Pierpaoli, C
通讯作者：
Pierpaoli, C
DOI：
10.1098/rspb.2006.3572
发表时间：
2006-09-07
影响因子：
4.7
作者：
Jones, Catherine M.;Healy, Susan D.
通讯作者：
Healy, Susan D.