ADHD and maturation of brain white matter: A DTI study in medication naive children and adults.
ADHD and maturation of brain white matter: A DTI study in medication naive children and adults.
复制标题
DOI：
10.1016/j.nicl.2017.09.026
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Reneman L
中科院分区：
文献类型：
--
作者：
Bouziane C;Caan MWA;Tamminga HGH;Schrantee A;Bottelier MA;de Ruiter MB;Kooij SJJ;Reneman L
注意缺陷多动障碍（ADHD）的几项扩散张量成像（DTI）研究显示，大脑白色物质（WM）发育延迟。由于这些研究主要在儿童和青少年中进行，因此这些WM异常已被假定，但未被证明可进展至成年。为了进一步了解注意缺陷多动障碍患者的WM成熟延迟的自然史，我们在这里研究了年龄对儿童和成人WM的调节作用。纳入120名未接受过兴奋剂治疗的ADHD男性儿童（10-12岁）和成人（23-40岁）ADHD（根据DSM-IV;所有亚型），沿着23名年龄和性别匹配的对照。分数各向异性（FA）值进行了比较，整个WM通过基于轨迹的空间统计（TBSS）和在特定区域的利益（ROI）。在TBSS和ROI分析中，我们发现，未接受过兴奋剂治疗的ADHD儿童与对照儿童的FA值没有差异，而成人ADHD受试者在几个地区与成人对照组相比FA值降低。全脑FA（p = 0.015）以及前丘脑辐射（p = 0.015）的显著年龄×组相互作用表明ADHD对脑WM的影响具有年龄依赖性。与先前在药物治疗的ADHD儿童中进行的研究相反，我们没有发现在刺激剂治疗初治的儿童中WM改变，只有治疗初治的成人。因此，我们的研究结果表明，报告的WM发育迟缓可能出现在童年之后，以前报告的ADHD儿童和正常发育的同龄人之间的差异可能归因于以前的ADHD药物，和/或其他影响WM发育的因素，如年龄和性别。在未接受过药物治疗的ADHD儿童中，白色物质的成熟没有延迟，只有在成人中才有。因此，ADHD的发育迟缓似乎出现在童年之后的青春期。与先前的研究不同，可能是影响WM发展的因素，如药物治疗状态，年龄和性别。
Several diffusion tensor imaging (DTI) studies in attention deficit hyperactivity disorder (ADHD) have shown a delay in brain white matter (WM) development. Because these studies were mainly conducted in children and adolescents, these WM abnormalities have been assumed, but not proven to progress into adulthood. To provide further insight in the natural history of WM maturation delay in ADHD, we here investigated the modulating effect of age on WM in children and adults. 120 stimulant-treatment naive male ADHD children (10–12 years of age) and adults (23–40 years of age) with ADHD (according to DSM-IV; all subtypes) were included, along with 23 age and gender matched controls. Fractional anisotropy (FA) values were compared throughout the WM by means of tract-based spatial statistics (TBSS) and in specific regions of interest (ROIs). On both TBSS and ROI analyses, we found that stimulant-treatment naive ADHD children did not differ in FA values from control children, whereas adult ADHD subjects had reduced FA values when compared to adult controls in several regions. Significant age × group interactions for whole brain FA (p = 0.015), as well as the anterior thalamic radiation (p = 0.015) suggest that ADHD affects the brain WM age-dependently. In contrast to prior studies conducted in medicated ADHD children, we did not find WM alterations in stimulant treatment naïve children, only treatment-naïve adults. Thus, our findings suggest that the reported developmental delay in WM might appear after childhood, and that previously reported differences between ADHD children and normal developing peers could have been attributed to prior ADHD medications, and/or other factors that affect WM development, such as age and gender. In medication naïve children with ADHD maturation of white matter was not delayed, only in adults. Thus, developmental delay in ADHD seems to appear after childhood, in adolescence. Discrepancy with prior studies likely underlie factors that affect WM development, such as medication status, age and gender.
登录
查看更多内容
影响因子：
1.7
作者：
Klingberg, T;Vaidya, CJ;Hedehus, M
通讯作者：
Hedehus, M
影响因子：
2.3
作者：
Dramsdahl, Margaretha;Westerhausen, Rene;Plessen, Kerstin J.
通讯作者：
Plessen, Kerstin J.
DOI：
10.1016/j.pnpbp.2015.04.008
发表时间：
2015-12-03
影响因子：
5.6
作者：
Onnink AM;Zwiers MP;Hoogman M;Mostert JC;Dammers J;Kan CC;Vasquez AA;Schene AH;Buitelaar J;Franke B
通讯作者：
Franke B
影响因子：
4.2
作者：
Kochunov, P.;Williamson, D. E.;Lancaster, J.;Fox, P.;Cornell, J.;Blangero, J.;Glahn, D. C.
通讯作者：
Glahn, D. C.
影响因子：
3.3
作者：
Durston, Sarah
通讯作者：
Durston, Sarah