A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness.
A review of chemical warfare agents linked to respiratory and neurological effects experienced in Gulf War Illness.
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DOI：
10.1080/08958378.2022.2147257
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发表时间：
2022
影响因子：
2.1
通讯作者：
中科院分区：
文献类型：
--
作者：
超过 40% 的波斯湾战争 (GW)（1990-1991）退伍军人患有海湾战争病 (GWI)。自 GW 以来三十年，导致 GWI 的暴露和机制仍不清楚。 GWI 可能造成的一种接触是化学战剂 (CWA)。虽然有针对 GWI 孤立症状的治疗方法，但呼吸系统和认知/神经系统问题的数量仍在增加，而治疗选择却很少。这个问题不仅影响到乔治城的退伍军人，重要的是，这些慢性多症状疾病在参加过阿富汗-伊拉克战争的退伍军人中也越来越多。两场战争的共同点是它们的区域和吸入暴露。在这篇综述中，我们将描述两次战争中沙林、环沙林和芥子气等 CWA 暴露，并讨论退伍军人经历的各种呼吸和神经认知问题。我们将把所经历的呼吸系统和神经系统症状与每个 CWA 所描述的各种潜在机制联系起来，并提供最新的模型和假设。
Over 40% of veterans from the Persian Gulf War (GW) (1990-1991) suffer from Gulf War Illness (GWI). Thirty years since the GW, the exposure and mechanism contributing to GWI remain unclear. One possible exposure that has been attributed to GWI are chemical warfare agents (CWA). While there are treatments for isolated symptoms of GWI, the number of respiratory and cognitive/neurological issues continues to rise with minimum treatment options. This issue doesn’t only affect veterans of the GW, importantly these chronic multisymptom illnesses are also growing amongst veterans who have served in the Afghanistan-Iraq war. What both wars have in common are their regions and inhaled exposures. In this review, we will describe the CWA exposures such as sarin, cyclosarin, and mustard gas in both wars and discuss the various respiratory and neurocognitive issues experienced by veterans. We will bridge the respiratory and neurological symptoms experienced to the various potential mechanisms described for each CWA provided with the most up-to-date models and hypotheses.
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海湾战争退伍军人与健康和有症状对照者血浆中枢神经系统蛋白自身抗体的性别差异。
影响因子：
3.3
作者：
Abou-Donia MB;Krengel MH;Lapadula ES;Zundel CG;LeClair J;Massaro J;Quinn E;Conboy LA;Kokkotou E;Nguyen DD;Abreu M;Klimas NG;Sullivan K
通讯作者：
Sullivan K
为什么G117H突变会大大改善人丁乙酸酯酶对Sarin的活性？量子机械/分子机械自由能计算的见解。
影响因子：
2.9
作者：
Yao Y;Liu J;Zhan CG
通讯作者：
Zhan CG
影响因子：
3.9
作者：
Bielmann, Andreas;Sambiagio, Nicolas;Curty, Christophe
通讯作者：
Curty, Christophe
DOI：
10.1016/j.bbi.2021.07.015
发表时间：
2021-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Bryant JD;Kodali M;Shuai B;Menissy SS;Graves PJ;Phan TT;Dantzer R;Shetty AK;Ciaccia West L;West AP
通讯作者：
West AP
影响因子：
2.8
作者：
Calvet, JH;Coste, A;Escudier, E
通讯作者：
Escudier, E