Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells.
Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells.
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全身性炎症标志物与流感疫苗抗体反应呈正相关，可能与ILT2(+)CD57(+) nk细胞有关。
DOI：
10.1186/s12979-022-00284-x
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发表时间：
2022-05-26
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
随着年龄的增长，整体健康状况下降，而全身性炎症介质水平往往会增加。尽管理解的基本机制知之甚少，但有大量数据表明，这种所谓的“炎症”有助于老年人发生不良后果的风险。我们试图确定系统性炎症的标志物是否与对季节性流感疫苗的抗体反应有关。在四个季节中，血凝抑制抗体滴度和外周外周血单核细胞（PBMC）对通过干扰素（IFN）-Cam/interleukin（IL）-10 -10产量评估的活流感病毒的反应，对年轻人和4周的成年人（N = 79）进行测量灭活疫苗（n = 612）。还测量了循环肿瘤坏死因子（TNF），白介素（IL）-6和C反应蛋白（CRP）的循环疫苗。疫苗后抗体滴度与全身性炎症水平显着相关。具体而言，IL-6与年轻人的A/H3N2滴度呈正相关（Cohen的D = 0.36），在较旧的高剂量（但没有标准剂量接受者）中，所有全身性炎症介体与A/H1N1，A/H1N1，A/H3N2和B滴度呈正相关（D = 0.10–0-0.45）。我们进一步表明，在随访的较老的高剂量接受者的后续队列中，ILT2（+）CD57（+）CD57（+）CD56-DIM天然杀手（NK） - 细胞与血浆IL-6和疫苗接种后A/H3N2滴度均呈正相关（n = 63）。途径分析表明，ILT2（+）CD57（+）DIM NK细胞介导了IL-6和A/H3N2滴度之间的关联的40％，这可能与潜在的参与者脆弱有关。总而言之，我们的数据表明，老年人中流感疫苗反应，全身性炎症和NK细胞表型之间存在复杂的关系，这在很大程度上取决于年龄，疫苗剂量以及可能的整体健康状况。尽管我们的结果表明“炎症”可能会增加老年人的疫苗免疫原性，但尚待确定这种增强是否有助于改善对流感疾病的保护。在线版本包含的补充材料可获得10.1186/s12979-022-00284-X。
With increasing age, overall health declines while systemic levels of inflammatory mediators tend to increase. Although the underlying mechanisms are poorly understood, there is a wealth of data suggesting that this so-called “inflammaging” contributes to the risk of adverse outcomes in older adults. We sought to determine whether markers of systemic inflammation were associated with antibody responses to the seasonal influenza vaccine. Over four seasons, hemagglutination inhibition antibody titres and ex vivo bulk peripheral blood mononuclear cell (PBMC) responses to live influenza viruses assessed via interferon (IFN)-γ/interleukin (IL)-10 production, were measured pre- and 4-weeks post-vaccination in young adults (n = 79) and older adults randomized to standard- or high-dose inactivated vaccine (n = 612). Circulating tumour necrosis factor (TNF), interleukin (IL)-6 and C-reactive protein (CRP) were also measured pre-vaccination. Post-vaccination antibody titres were significantly associated with systemic inflammatory levels; specifically, IL-6 was positively associated with A/H3N2 titres in young adults (Cohen’s d = 0.36), and in older high-dose, but not standard-dose recipients, all systemic inflammatory mediators were positively associated with A/H1N1, A/H3N2 and B titres (d = 0.10–0.45). We further show that the frequency of ILT2(+)CD57(+) CD56-Dim natural killer (NK)-cells was positively associated with both plasma IL-6 and post-vaccination A/H3N2 titres in a follow-up cohort of older high-dose recipients (n = 63). Pathway analysis suggested that ILT2(+)CD57(+) Dim NK-cells mediated 40% of the association between IL-6 and A/H3N2 titres, which may be related to underlying participant frailty. In summary, our data suggest a complex relationship amongst influenza vaccine responses, systemic inflammation and NK-cell phenotype in older adults, which depends heavily on age, vaccine dose and possibly overall health status. While our results suggest that “inflammaging” may increase vaccine immunogenicity in older adults, it is yet to be determined whether this enhancement contributes to improved protection against influenza disease. The online version contains supplementary material available at 10.1186/s12979-022-00284-x.
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影响因子：
4.6
作者：
Gomez CR;Karavitis J;Palmer JL;Faunce DE;Ramirez L;Nomellini V;Kovacs EJ
通讯作者：
Kovacs EJ
影响因子：
6.3
作者：
Giovannini S;Onder G;Liperoti R;Russo A;Carter C;Capoluongo E;Pahor M;Bernabei R;Landi F
通讯作者：
Landi F
DOI：
10.1186/s12979-020-00210-z
发表时间：
2020-11-19
期刊：
Immunity & ageing : I & A
影响因子：
--
作者：
Frasca D;Blomberg BB
通讯作者：
Blomberg BB
DOI：
10.1073/pnas.1617959114
发表时间：
2017-01-31
影响因子：
11.1
作者：
de Bourcy, Charles F. A.;Angel, Cesar J. Lopez;Quake, Stephen R.
通讯作者：
Quake, Stephen R.
影响因子：
4.6
作者：
Alberro A;Iribarren-Lopez A;Sáenz-Cuesta M;Matheu A;Vergara I;Otaegui D
通讯作者：
Otaegui D