Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency.
Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency.
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DOI：
10.1038/s41598-021-83991-7
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发表时间：
2021-02-23
影响因子：
4.6
通讯作者：
Otaegui D
中科院分区：
文献类型：
--
作者：
Alberro A;Iribarren-Lopez A;Sáenz-Cuesta M;Matheu A;Vergara I;Otaegui D
生活质量的提高和医学的进步导致了预期寿命的延长。尽管如此，在生命的最后几年，健康状况通常会恶化。脆弱是一种中间的可逆状态，通常先于依赖，因此，识别脆弱对于防止依赖可能是必不可少的。然而，对于识别脆弱性的最佳工具，还没有达成共识。在这个意义上，不同的分子被认为是潜在的生物标记物。一些调查指出慢性炎症或虚弱的炎症增加，而另一些调查则没有报告这种差异。在这项工作中，我们用ELISA和Luminex技术评估了成年人和老年人(70岁以上)的炎症标志物的循环浓度。采用Barthel指数评定依赖程度，采用计时起跳、步速、短体能电池、Tilburg脆弱指数和Gerontopole脆弱筛查工具进行脆弱识别。我们测量了C反应蛋白、肿瘤坏死因子-α、IL-6和白蛋白浓度，发现老年人存在炎症升高，而与虚弱和依赖没有差异。我们的结果对于所有评估的脆弱程度都是一致的，强调了需要重新考虑将炎症增加作为脆弱的生物标记物。
The improvement of life quality and medical advances has resulted in increased life expectancy. Despite this, health status commonly worsens in the last years of life. Frailty is an intermediate and reversible state that often precedes dependency and therefore, its identification may be essential to prevent dependency. However, there is no consensus on the best tools to identify frailty. In this sense, diverse molecules have been proposed as potential biomarkers. Some investigations pointed to an increased chronic inflammation or inflammaging with frailty, while others did not report such differences. In this work, we evaluated the circulating concentration of the inflammaging markers in adults and older adults (aged over 70 years) by ELISA and Luminex techniques. The Barthel Index was applied for the evaluation of dependency and Timed up-and-go, Gait Speed, Short Physical Performance Battery, Tilburg Frailty Indicator and Gerontopole Frailty Screening Tool were used for the identification of frailty. CRP, TNF-α, IL-6 and albumin concentrations were measured, and we found that elevated inflammation is present in older adults, while no differences with frailty and dependency were reported. Our results were consistent for all the evaluated frailty scales, highlighting the need to reconsider increased inflammation as a biomarker of frailty.
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影响因子：
3.6
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Otaegui D