REVIEW ■ : LTP and LTD: Dynamic and Interactive Processes of Synaptic Plasticity
REVIEW ■ : LTP and LTD: Dynamic and Interactive Processes of Synaptic Plasticity
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回顾：LTP 和 LTD：突触可塑性的动态和交互过程
DOI：
--
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
R. Malenka
中科院分区：
文献类型：
--
作者：
R. Malenka
突触传递效率的长期、活动依赖的变化被认为对信息的存储和神经回路的发展具有重要意义。这种变化的主要实验模型是长时程增强(LTP)，这是突触强度的长期增加。对海马体中LTP的密集实验分析导致了对其产生的初始步骤的详细描述。最近，一种形式的长期抑郁(LTD)在海马区已被描述和检查。它与LTP有几个共同的机械特征，似乎能够逆转LTP。产生和维持LTP和LTD所需的细胞内第二信使系统一直很难确定。主要候选者包括可扩散的细胞间信使以及蛋白激酶和蛋白磷酸酶，它们的活性可能在特定的磷酸蛋白水平上聚集。除了描述LTP和LTD下的细胞机制外，研究人员还开始澄清它们在真实学习和记忆中所扮演的角色。神经科学家1：35-42,1995
Long-lasting, activity-dependent changes in the efficacy of synaptic transmission are considered to be of fundamental importance for the storage of information and for the development of neural circuitry. The leading experimental model for such a change has been long-term potentiation (LTP), a long-lasting increase in synaptic strength. Intensive experimental analysis of LTP in the hippocampus has resulted in a detailed description of the initial steps responsible for its generation. Recently, a form of long-term depression (LTD) in the hippocampus has been described and examined. It shares several mechanistic features with LTP and appears to be able to reverse LTP. The intracellular second messenger systems that are required to generate and maintain LTP and LTD have been difficult to identify definitively. Leading candidates include diffusible intercellular messengers as well as protein kinases and protein phosphatases, the activities of which may converge at the level of specific phosphoproteins. In addition to delineating the cellular mechanisms under lying LTP and LTD, investigators also are beginning to clarify the roles they play in real learning and memory. The Neuroscientist 1:35-42, 1995
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影响因子：
56.9
作者：
WILSON, MA;MCNAUGHTON, BL
通讯作者：
MCNAUGHTON, BL
影响因子：
56.9
作者：
MULKEY, RM;HERRON, CE;MALENKA, RC
通讯作者：
MALENKA, RC
影响因子：
2
作者：
T. O’Dell;E. Kandel
通讯作者：
T. O’Dell;E. Kandel
DOI：
10.1073/pnas.90.18.8342
发表时间：
1993-09-15
影响因子：
11.1
作者：
SACKTOR, TC;OSTEN, P;SUBLETTE, E
通讯作者：
SUBLETTE, E
影响因子：
56.9
作者：
HUANG, YY;COLINO, A;MALENKA, RC
通讯作者：
MALENKA, RC