Increased synapses in the medial prefrontal cortex are associated with repeated amphetamine administration.
Increased synapses in the medial prefrontal cortex are associated with repeated amphetamine administration.
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DOI：
10.1002/syn.20591
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发表时间：
2009-02
期刊：
影响因子：
2.3
通讯作者：
Meredith, Gloria E.
中科院分区：
文献类型：
--
作者：
Morshedi, Maud M.;Rademacher, David J.;Meredith, Gloria E.
精神兴奋剂药物不仅会导致行为的长期改变，而且还会改变内侧前额皮质锥体神经元的活动和形态。本研究的目的是确定反复使用安非他明治疗大鼠是否伴随着内侧前额叶皮层（mPFC）突触模式或类型的变化，特别是投射到外侧下丘脑的神经元，我们早期的工作已经显示反复使用安非他明后神经元活动标记物增加。用安非他明的行为致敏方案治疗大鼠，随后用无偏体视学（物理定向仪和电子显微镜）分析mPFC边缘下和边缘前皮层的突触。所有的突触都被计数，它们的目标被标准的方法学标准确定。反复服用安非他明与不对称轴突突触数量显著增加有关，与给药大鼠相比，轴突或轴体接触没有变化，下丘脑皮质外侧锥体神经元突触总数没有变化。因此，由于反复暴露于安非他明而导致的行为致敏伴随着脊柱突触的增加，而不是正中前额皮质锥体神经元上的树突突触的增加。
Psychostimulant drug experience leads not only to long-lasting changes in behavior but also modifications in the activity and morphology of pyramidal neurons in the medial prefrontal cortex. The objective of the present study was to establish whether repeated treatment of rats with amphetamine is accompanied by changes in the pattern or types of synapses in the medial prefrontal cortex (mPFC) and, specifically, onto neurons that project to the lateral hypothalamus, where our earlier work has shown increased markers of neuronal activity after repeated amphetamine treatment. Rats were treated with a behaviorally sensitizing regimen of amphetamine, following which synapses in the infralimbic and prelimbic cortices of the mPFC, were analyzed with unbiased stereology (physical disector and electron microscopy). All synapses were counted and their targets identified by standard methodological criteria. Repeated amphetamine administration was associated with a significant increase in the number of asymmetric axospinous synapses, no change in axodendritic or axosomatic contacts, and no change in the total number of synapses on corticolateral hypothalamic pyramidal neurons compared to vehicle-treated rats. Therefore, behavioral sensitization as a result of repeated exposure to amphetamine is accompanied by the increased formation of spine, but not dendritic, synapses onto pyramidal neurons in the medial prefrontal cortex.
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影响因子：
3
作者：
BRAENDGAARD, H;GUNDERSEN, HJG
通讯作者：
GUNDERSEN, HJG
影响因子：
15.9
作者：
COGGESHALL, RE
通讯作者：
COGGESHALL, RE
DOI：
10.1007/bf02284843
发表时间：
1996-12-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Geinisman, Y;Gundersen, HJG;West, MJ
通讯作者：
West, MJ
影响因子：
3
作者：
DEGROOT, DMG;BIERMAN, EPB
通讯作者：
BIERMAN, EPB
影响因子：
3.4
作者：
Morshedi, Maud M.;Meredith, Gloria E.
通讯作者：
Meredith, Gloria E.