Reward magnitude tracking by neural populations in ventral striatum.
Reward magnitude tracking by neural populations in ventral striatum.
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DOI：
10.1016/j.neuroimage.2016.10.036
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发表时间：
2017-02-01
期刊：
影响因子：
5.7
通讯作者：
Jasanoff A
中科院分区：
文献类型：
--
作者：
Fiallos AM;Bricault SJ;Cai LX;Worku HA;Colonnese MT;Westmeyer GG;Jasanoff A
评价内在奖励刺激的大小对于分配价值和指导行为是必不可少的。通过结合参数操纵的主要奖励，内侧前脑束（MFB）微刺激，与功能磁成像（fMRI）在啮齿动物，我们描绘了一个广泛的网络结构激活的行为特征的奖励刺激水平。相关性的心理行为测量功能磁共振成像反应幅度显示区域的活动密切对应的主观奖励幅度。最大和最可靠的奖励幅度跟踪的焦点被观察到在壳区的核丘脑（NAc）。虽然神经血管耦合的非线性性质复杂的功能磁共振成像研究结果的解释，在精确的神经生理学术语，奖励幅度跟踪没有观察到在血管室，不能解释饱和的区域特定的血流动力学反应。此外，NAc的局部药理学失活改变了动物对不同幅度奖励的反应，而不改变平均奖励反应率，进一步支持了该区域神经群体活动有助于评估奖励幅度的假设。
Evaluation of the magnitudes of intrinsically rewarding stimuli is essential for assigning value and guiding behavior. By combining parametric manipulation of a primary reward, medial forebrain bundle (MFB) microstimulation, with functional magnetic imaging (fMRI) in rodents, we delineated a broad network of structures activated by behaviorally characterized levels of rewarding stimulation. Correlation of psychometric behavioral measurements with fMRI response magnitudes revealed regions whose activity corresponded closely to the subjective magnitude of rewards. The largest and most reliable focus of reward magnitude tracking was observed in the shell region of the nucleus accumbens (NAc). Although the nonlinear nature of neurovascular coupling complicates interpretation of fMRI findings in precise neurophysiological terms, reward magnitude tracking was not observed in vascular compartments and could not be explained by saturation of region-specific hemodynamic responses. In addition, local pharmacological inactivation of NAc changed the profile of animals’ responses to rewards of different magnitudes without altering mean reward response rates, further supporting a hypothesis that neural population activity in this region contributes to assessment of reward magnitudes.
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影响因子：
3.7
作者：
Kim KM;Baratta MV;Yang A;Lee D;Boyden ES;Fiorillo CD
通讯作者：
Fiorillo CD
影响因子：
4.7
作者：
Carlezon WA Jr;Thomas MJ
通讯作者：
Thomas MJ
DOI：
10.1523/jneurosci.6491-10.2011
发表时间：
2011-05-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ambroggi F;Ghazizadeh A;Nicola SM;Fields HL
通讯作者：
Fields HL
影响因子：
1.9
作者：
GALLISTEL, CR;LEON, M
通讯作者：
LEON, M
DOI：
10.1037/h0077513
发表时间：
1978-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
GALLISTEL, CR
通讯作者：
GALLISTEL, CR