Birth characteristics and risk of febrile seizures.
Birth characteristics and risk of febrile seizures.
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DOI：
10.1111/ane.13420
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发表时间：
2021-07
影响因子：
3.5
通讯作者：
Christensen J
中科院分区：
文献类型：
--
作者：
Christensen KJ;Dreier JW;Skotte L;Feenstra B;Grove J;Børglum A;Mitrovic M;Cotsapas C;Christensen J
发热性癫痫是一种常见的儿童疾病，影响2%-5%的儿童，并与后来的癫痫和精神障碍的发展有关。这项研究确定了热性癫痫的发生率与出生特征、年龄、性别和大脑发育的关系。这是一项队列研究，研究对象是1977至2011年间出生于丹麦的所有3个月大的儿童(N=2,103,232)。丹麦国家患者登记簿用于识别5岁以下发热性癫痫的儿童。后续行动于2016年12月31日结束，当时所有队列成员可能已满5岁。总共有75,593人(3.59%，95%CI：3.57-3.62%)被诊断为热性惊厥。发病率在16.7个月龄时达到高峰(中位数：16.7个月，四分位数范围：12.5-24.0)。随着出生体重的降低(<；1500 g；5.42%(95%CI：4.98-5.88%vs.3,000-4,000 g；3.53%(95%CI：3.50-3.56%))和出生时胎龄的降低(31-32周；5.90%(95%CI：5.40-6.44%)对39-40周；3.56%(95%CI：3.53-3.60))，5年累计热性惊厥发生率增加。出生时胎龄较低与首次发热性癫痫发作时的较高年龄相关；当根据受孕年龄进行校正时，这种关联基本上消失了。随着出生体重和出生时胎龄的降低，高热性癫痫发作的风险增加。出生时低胎龄和首次热性惊厥年龄之间的关联表明，热性惊厥的发生与大脑发育阶段有关。
Febrile seizure is a common childhood disorder that affects 2-5% of all children, and is associated with later development of epilepsy and psychiatric disorders. This study determines how the incidence of febrile seizures correlates with birth characteristics, age, sex, and brain development. This is a cohort study of all children born Denmark between 1977 and 2011 who were alive at 3 months of age (N = 2,103,232). The Danish National Patient Register was used to identify children with febrile seizures up to 5 years of age. Follow-up ended on 31 December 2016 when all cohort members had potentially reached 5 years of age. In total, 75,593 (3.59%, 95% CI: 3.57-3.62%) were diagnosed with febrile seizures. Incidence peaked at 16.7 months of age (median: 16.7 months, interquartile range: 12.5-24.0). The 5-year cumulative incidence of febrile seizures increased with decreasing birth weight (<1500 g; 5.42% (95% CI: 4.98-5.88% vs. 3,000-4,000 g; 3.53% (95% CI: 3.50-3.56%)), and with decreasing gestational age at birth (31-32 weeks; 5.90% (95% CI: 5.40-6.44%) vs. 39-40 weeks; 3.56% (95% CI: 3.53-3.60)). Lower gestational age at birth was associated with higher age at onset of a first febrile seizure; an association that essentially disappeared when correcting for age from conception. The risk of febrile seizures increased with decreasing birth weight and gestational age at birth. The association between low gestational age at birth and age at first febrile seizure suggest that onset of febrile seizures is associated with the stage of brain development.
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