Manipulation of host cell plasma membranes by intracellular bacterial pathogens.
Manipulation of host cell plasma membranes by intracellular bacterial pathogens.
复制标题
细胞内细菌病原体对宿主细胞质膜的操纵。
DOI：
10.1016/j.mib.2022.102241
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发表时间：
2023
影响因子：
5.4
通讯作者：
Welch,MatthewD
中科院分区：
文献类型：
--
作者：
Kostow,Nora;Welch,MatthewD
细胞质膜的操纵是细胞内细菌病原体感染的关键。质膜操纵发生在细菌进入和离开宿主细胞的过程中。细菌使用不同的策略来靶向质膜组分、组成和形状。细菌利用质膜相关的途径，如信号转导、内吞、胞吞和胞吞作用，在细胞内细菌病原体感染期间，特别是在细菌进入和离开宿主细胞期间，宿主细胞质膜的操纵是关键的。为了操纵宿主细胞，细菌部署调节或修改宿主细胞组分的分泌蛋白。在这里，我们回顾了最近的进展，建议共同的主题，细菌操纵宿主细胞质膜。一个主题是细菌使用不同的策略来靶向或影响宿主细胞质膜的组成和形状。第二个主题是细菌利用宿主细胞质膜相关的途径，如信号转导，内吞作用和胞吐作用。未来的研究如何细菌和宿主因素有助于质膜操纵细菌病原体将揭示新的见解的发病机制和质膜生物学的基本原则。
HighlightsManipulation of the host cell plasma membrane is critical for infection by intracellular bacterial pathogens.Plasma membrane manipulation occurs during bacterial entry and exit from host cells.Bacteria use diverse strategies to target plasma membrane components, composition, and shape.Bacteria take advantage of plasma membrane-associated pathways such as signal transduction, endocytosis, and exocytosis.Manipulation of the host cell plasma membrane is critical during infection by intracellular bacterial pathogens, particularly during bacterial entry into and exit from host cells. To manipulate host cells, bacteria deploy secreted proteins that modulate or modify host cell components. Here, we review recent advances that suggest common themes by which bacteria manipulate the host cell plasma membrane. One theme is that bacteria use diverse strategies to target or influence host cell plasma membrane composition and shape. A second theme is that bacteria take advantage of host cell plasma membrane-associated pathways such as signal transduction, endocytosis, and exocytosis. Future investigation into how bacterial and host factors contribute to plasma membrane manipulation by bacterial pathogens will reveal new insights into pathogenesis and fundamental principles of plasma membrane biology.
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影响因子：
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作者：
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DOI：
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发表时间：
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DOI：
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