Measuring health-related quality of life in men with osteoporosis or osteoporotic fracture.
Measuring health-related quality of life in men with osteoporosis or osteoporotic fracture.
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DOI：
10.1186/1471-2458-11-775
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发表时间：
2011-10-09
影响因子：
4.5
通讯作者：
Diez-Perez A
中科院分区：
文献类型：
--
作者：
Zwart M;Azagra R;Encabo G;Aguye A;Roca G;Güell S;Puchol N;Gene E;López-Expósito F;Solà S;Ortiz S;Sancho P;Abado L;Iglesias M;Pujol-Salud J;Diez-Perez A
骨质疏松症是一种严重的健康问题，由于骨质疏松性骨折，该疾病会降低患者的生活质量和生存率。长期以来，研究一直集中在女性身上，而它在男性中的存在却被低估了。虽然在不同国家进行的许多研究主要评估女性与健康相关的生活质量并确定女性骨折风险因素，但关于西班牙男性人群的数据很少。观察性研究。年龄≥ 40 岁的男性，有/没有被家庭医生诊断为骨质疏松症以及有/没有骨质疏松性骨折。西班牙男性人群中骨质疏松性骨折的常见临床危险因素与健康相关生活质量之间的关系。制作了与健康相关的生活质量的电话调查问卷。定性变量之间的关联将通过卡方检验进行评估。通过学生 t 检验得出定量变量的分布。如果不满足使用此检验的条件，则将使用非参数 Mann-Whitney's U 检验。 FRAX™ 工具获得的结果的验证将通过 Hosmer-Lemeshow 测试并计算接受者操作特征 (ROC) 曲线 (AUC) 下的面积来进行。所有测试均将以设置为 95% 的置信区间进行。健康相关生活质量 (HRQOL) 研究的适用性和有用性在许多国家都有详细记录。这些研究允许在特定疾病的情况下实施具有成本效益的措施，并减少由此产生的代价高昂的后果。这项研究试图提供关于西班牙男性人群骨质疏松症临床方面如何影响生活质量的客观数据，并且对于卫生当局进行的成本效用分析也很有用。所选样本并非基于高骨折风险群体。相反，它是由一般人口中的男性组成的，因此比较不应导致错误的解释。通过对照医疗报告和 X 射线检查报告的骨折情况，或咨询适用的医疗保健中心，可确保可能的偏差纠正。
Osteoporosis is a serious health problem that worsens the quality of life and the survival rate of individuals with this disease on account the osteoporotic fractures. Studies have long focused on women, and its presence in men has been underestimated. While many studies conducted in different countries mainly assess health-related quality of life and identify fracture risks factors in women, few data are available on a Spanish male population. Observational study. Men ≥ 40 years of age with/without diagnosed osteoporosis and with/without osteoporotic fracture included by their family doctor. The relationship between customary clinical risk factors for osteoporotic fracture and health-related quality of life in a Spanish male population. A telephone questionnaire on health-related quality of life is made. The association between qualitative variables will be assessed by the Chi-square test. The distribution of quantitative variables by Student's t-test. If the conditions for using this test are not met, the non-parametric Mann-Whitney's U test will be used. The validation of the results obtained by the FRAX™ tool will be performed by way of the Hosmer-Lemeshow test and by calculating the area under the Receiver Operating Characteristic (ROC) curve (AUC). All tests will be performed with a confidence intervals set at 95%. The applicability and usefulness of Health-related quality of life (HRQOL) studies are well documented in many countries. These studies allow implementing cost-effective measures in cases of a given disease and reducing the costly consequences derived therefrom. This study attempts to provide objective data on how quality of life is affected by the clinical aspects involved in osteoporosis in a Spanish male population and can be useful as well in cost utility analyses conducted by health authorities. The sample selected is not based on a high fracture risk group. Rather, it is composed of men in the general population, and accordingly comparisons should not lead to erroneous interpretations. A possible bias correction will be ensured by checking reported fractures against healthcare reports and X-rays, or by consulting health care centers as applicable.
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影响因子：
4.2
作者：
Yu, Elaine W.;Blackwell, Terri;Ensrud, Kristine E.;Hillier, Teresa A.;Lane, Nancy E.;Orwoll, Eric;Bauer, Douglas C.
通讯作者：
Bauer, Douglas C.
影响因子：
4
作者：
Magnus, JH;Broussard, DL
通讯作者：
Broussard, DL
影响因子：
168.9
作者：
Center, JR;Nguyen, TV;Eisman, JA
通讯作者：
Eisman, JA
影响因子：
4
作者：
Pinheiro, M. M.;Ciconelli, R. M.;Ferraz, M. B.
通讯作者：
Ferraz, M. B.
影响因子：
4.2
作者：
Kanis, JA;Johnell, O;Mellstrom, D
通讯作者：
Mellstrom, D