Acid-suppressive medications and risk of bone loss and fracture in older adults.
Acid-suppressive medications and risk of bone loss and fracture in older adults.
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DOI：
10.1007/s00223-008-9170-1
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发表时间：
2008-10
影响因子：
4.2
通讯作者：
Bauer, Douglas C.
中科院分区：
文献类型：
--
作者：
Yu, Elaine W.;Blackwell, Terri;Ensrud, Kristine E.;Hillier, Teresa A.;Lane, Nancy E.;Orwoll, Eric;Bauer, Douglas C.
最近的研究表明，使用抑酸药物会增加骨折的风险。我们研究了两组年龄在65岁以上的男性和女性，他们分别参加了男性骨质疏松性骨折研究（MrOS）和骨质疏松性骨折研究（SOF）。我们测量了5755名男性和5339名女性的DXA，并评估了ppi和/或H2RAs的基线使用情况。重新评估药物使用和重复BMD，并记录髋部和其他非脊柱骨折的评估。在多变量分析中，使用PPIs或H2RAs的男性横截面骨量较低。在女性中没有观察到明显的骨密度差异。然而，使用PPIs的女性发生非脊柱骨折的风险增加（RH=1.34; 95% CI 1.10-1.64）。PPI的使用也与男性非脊柱骨折风险增加相关，但仅适用于未服用钙补充剂的人群（RH=1.49; 95% CI 1.04-2.14）。在男性和女性中，使用H2RA与非脊柱骨折无关，使用H2RA和PPI均与髋部骨折发生率无关。在老年女性和钙摄入量低的老年男性中使用质子泵抑制剂可能与非脊柱骨折的风险适度增加有关。
Recent studies have suggested an increased fracture risk with acid-suppressive medication use. We studied two cohorts of men and women over age 65 who were enrolled in the Osteoporotic Fractures in Men Study (MrOS) and the Study of Osteoporotic Fractures (SOF), respectively. We measured DXA and assessed baseline use of PPIs and/or H2RAs in 5755 men and 5339 women. Reassessment of medication use and repeat BMD were performed, and assessment of hip and other non-spine fractures were documented. On multivariate analysis, men using either PPIs or H2RAs had lower cross-sectional bone mass. No significant BMD differences were observed among women. However, there was an increased risk of non-spine fracture among women using PPIs (RH=1.34; 95% CI 1.10-1.64). PPI use was also associated with an increased risk of non-spine fracture in men, but only among those who were not taking calcium supplements (RH=1.49; 95% CI 1.04-2.14). H2RA use was not associated with non-spine fractures, and neither H2RA nor PPI use was associated with incident hip fractures in men or women. The use of PPIs in older women, and perhaps older men with low calcium intake, may be associated with a modest increased risk of non-spine fracture.
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影响因子：
120.7
作者：
CUMMINGS, SR;BLACK, DM;VOGT, TM
通讯作者：
VOGT, TM
DOI：
10.7326/0003-4819-127-8_part_2-199710151-00064
发表时间：
1997-10-15
影响因子：
39.2
作者：
Rubin, DB
通讯作者：
Rubin, DB
影响因子：
2.2
作者：
Orwoll, E;Blank, JB;Stone, K
通讯作者：
Stone, K
影响因子：
2.5
作者：
Graziani, G;Badalamenti, S;Ponticelli, C
通讯作者：
Ponticelli, C
DOI：
10.1016/s1529-9430(03)00024-x
发表时间：
2003-07-01
期刊：
The spine journal : official journal of the North American Spine Society
影响因子：
--
作者：
Vogt, Molly T;Rubin, David A;Cauley, Jane A
通讯作者：
Cauley, Jane A