Large fluctuations in the effective population size of the malaria mosquito Anopheles gambiae s.s. during vector control cycle.

Large fluctuations in the effective population size of the malaria mosquito Anopheles gambiae s.s. during vector control cycle.
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DOI:
10.1111/eva.12094
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发表时间:
2013-12
影响因子:
4.1
通讯作者:
Slotman MA
Slotman MA
中科院分区:
生物学2区
文献类型:
--
作者:
Hodges TK;Athrey G;Deitz KC;Overgaard HJ;Matias A;Caccone A;Slotman MA

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在赤道几内亚比奥科岛,自2004年初以来,室内滞留喷洒一直是比奥科岛疟疾控制项目的一部分。尽管在减少儿童感染方面取得了成功,但岛上的高传播地区仍然存在。因此,我们在持续高传播的地区对冈比亚按蚊有效种群大小(Ne)的波动进行了两轮喷雾试验。我们分析了791 An地区13个微卫星位点的数据。在2009年和2010年的六个时间点收集冈比亚标本,并使用近似贝叶斯计算(ABC)重建了这一时期的人口统计历史。我们的分析表明,IRS轮对Ne有很大的影响,比预喷轮减少了65%-92%。更重要的是,我们的分析显示,3-5个月后,安。冈比亚种群数量在喷洒后不久反弹了2818%。我们的研究强调了适当的喷轮频率对于持续抑制蚊子种群的重要性,并且增加喷轮频率应该大大提高IRS运动的效果。它还证明了ABC能够在一个庞大的人口中重建几十代人的详细人口统计历史。
On Bioko Island, Equatorial Guinea, indoor residual spraying (IRS) has been part of the Bioko Island Malaria Control Project since early 2004. Despite success in reducing childhood infections, areas of high transmission remain on the island. We therefore examined fluctuations in the effective population size (Ne) of the malaria vector Anopheles gambiae in an area of persistent high transmission over two spray rounds. We analyzed data for 13 microsatellite loci from 791 An. gambiae specimens collected at six time points in 2009 and 2010 and reconstructed the demographic history of the population during this period using approximate Bayesian computation (ABC). Our analysis shows that IRS rounds have a large impact on Ne, reducing it by 65%–92% from prespray round Ne. More importantly, our analysis shows that after 3–5 months, the An. gambiae population rebounded by 2818% compared shortly following the spray round. Our study underscores the importance of adequate spray round frequency to provide continuous suppression of mosquito populations and that increased spray round frequency should substantially improve the efficacy of IRS campaigns. It also demonstrates the ability of ABC to reconstruct a detailed demographic history across only a few tens of generations in a large population.
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