Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats.
Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats.
复制标题
DOI：
10.1016/j.psyneuen.2008.06.012
复制
发表时间：
2008-10
影响因子：
3.7
通讯作者：
McCarson, Kenneth. E.
中科院分区：
文献类型：
--
作者：
Levant, Beth;Ozias, Marlies K.;Davis, Paul F.;Winter, Michelle;Russell, Kristin L.;Carlson, Susan E.;Reed, Gregory A.;McCarson, Kenneth. E.
关键词：
二十二碳六烯酸（DHA; 22：6 n-3）的组织水平降低与非产后抑郁症和产后抑郁症的病因有关。为了确定脑DHA含量减少的神经生物学后遗症，本研究检查了成年雌性Long-Evans大鼠脑DHA含量损失和并发生殖状态的影响。使用α-亚麻酸缺乏饮食和育种方案生产皮质磷脂DHA水平比喂食含充足α-亚麻酸的对照饮食的未交配和经产雌性大鼠低23-26%的未交配和经产雌性大鼠。在第二窝断奶（出生后第20天）时对经产母鼠进行检测/人道处死;在间情期期间对未交配母鼠进行检测/人道处死。无论生殖状态如何，脑DHA的减少与海马BDNF基因表达的减少和对强烈应激的相对皮质酮反应的增加有关。与大脑DHA正常的处女女性相比，大脑DHA减少的处女女性中，额叶皮质中的5-羟色胺含量和周转率降低。与DHA正常的经产母鼠相比，大脑DHA减少的经产母鼠海马中5-HT 1A受体的密度增加，对强烈应激源的皮质酮反应增加，强迫游泳试验中不动的潜伏期减少。这些发现表明，神经生物学的变化可归因于大脑DHA的减少或经产状态和大脑DHA水平的相互作用。此外，这些数据与抑郁症患者的研究结果一致，因此支持DHA作为抑郁症病因的一个因素，特别是产后抑郁症。
Decreased tissue levels of docosahexaenoic acid (DHA; 22:6n-3) are implicated in the etiologies of non-puerperal and postpartum depression. With the aim of determining neurobiological sequelae of decreased brain DHA content, this study examined the effects of a loss of brain DHA content and concurrent reproductive status in adult female Long-Evans rats. An α-linolenic acid-deficient diet and breeding protocols were used to produce virgin and parous female rats with cortical phospholipid DHA levels 23–26% lower than virgin and parous rats fed a control diet containing adequate α-linolenic acid. Parous dams were tested/euthanized at weaning (postnatal day 20) of the second litter; virgin females, during diestrus. Decreased brain DHA was associated with decreased hippocampal BDNF gene expression and increased relative corticosterone response to an intense stressor, regardless of reproductive status. In virgin females with decreased brain DHA, serotonin content and turnover in frontal cortex were decreased compared to virgin females with normal brain DHA. In parous dams with decreased brain DHA, the density of 5-HT1A receptors in the hippocampus was increased, corticosterone response to an intense stressor was increased, and the latency to immobility in the forced swim test was decreased compared to parous dams with normal DHA. These findings demonstrate neurobiological alterations attributable to decreased brain DHA or an interaction of parous status and brain DHA level. Furthermore, the data are consistent with findings in depressed humans, and thus support a role for DHA as a factor in the etiologies of depressive illnesses, particularly postpartum depression.
登录
查看更多内容
影响因子：
3.3
作者：
Duric, V;McCarson, KE
通讯作者：
McCarson, KE
影响因子：
2.5
作者：
CLANDININ, MT;CHAPPELL, JE;CHANCE, GW
通讯作者：
CHANCE, GW
DOI：
10.1126/stke.2252004re5
发表时间：
2004-03-16
期刊：
Science's STKE : signal transduction knowledge environment
影响因子：
--
作者：
Charney, Dennis S;Manji, Husseini K
通讯作者：
Manji, Husseini K
影响因子：
6.9
作者：
CARROLL, BJ;CURTIS, GC;SUGERMAN, AA
通讯作者：
SUGERMAN, AA
影响因子：
17.7
作者：
CARPENTER, WT;BUNNEY, WE
通讯作者：
BUNNEY, WE