Enhanced Effects of Chronic Restraint-Induced Psychological Stress on Total Body Fe-Irradiation-Induced Hematopoietic Toxicity in Trp53-Heterozygous Mice.
Enhanced Effects of Chronic Restraint-Induced Psychological Stress on Total Body Fe-Irradiation-Induced Hematopoietic Toxicity in Trp53-Heterozygous Mice.
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DOI：
10.3390/life12040565
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发表时间：
2022-04-10
期刊：
影响因子：
3.2
通讯作者：
Nenoi, Mitsuru
中科院分区：
文献类型：
--
作者：
Wang, Bing;Katsube, Takanori;Tanaka, Kaoru;Ninomiya, Yasuharu;Hirakawa, Hirokazu;Liu, Cuihua;Maruyama, Kouichi;Vares, Guillaume;Kito, Seiji;Nakajima, Tetsuo;Fujimori, Akira;Nenoi, Mitsuru
关键词：
在载人深空飞行任务等某些情况下，人类既暴露于心理压力（PS），也暴露于辐射。核实这种同时接触可能会增强有害影响是一个非常令人关切的问题。先驱研究表明，慢性限制诱导PS（CRIPS）可以减弱Trp 53功能，并增加γ射线诱导的Trp 53杂合子小鼠的致癌作用，而CRIPS没有显着改变X射线诱导的Trp 53野生型小鼠的造血毒性的影响。由于高线性能量转移（LET）辐射是空间辐射生物学效应中最重要的组成部分，我们进一步研究了CRIPS对高LET铁粒子辐射（Fe）诱导的Trp 53杂合子小鼠造血毒性的影响。结果表明，CRIPS单独使用几乎不会引起血液学参数（外周血象和骨髓中的微核红细胞）的显著变化，而同时暴露则会导致遗传毒性升高（测量为红细胞中的微核发生率）。特别是，暴露于低剂量（0.1戈伊）的CRISP或Fe粒子辐射不会诱导微核发生率显著增加;然而，同时暴露导致微核发生率显著增加。这些发现表明，CRIPS可以增强高LET辐射的有害影响，特别是在低剂量下，对Trp 53杂合子小鼠的造血毒性。
Humans are exposed to both psychological stress (PS) and radiation in some scenarios such as manned deep-space missions. It is of great concern to verify possible enhanced deleterious effects from such concurrent exposure. Pioneer studies showed that chronic restraint-induced PS (CRIPS) could attenuate Trp53 functions and increase gamma-ray-induced carcinogenesis in Trp53-heterozygous mice while CRIPS did not significantly modify the effects on X-ray-induced hematopoietic toxicity in Trp53 wild-type mice. As high-linear energy transfer (LET) radiation is the most important component of space radiation in causing biological effects, we further investigated the effects of CRIPS on high-LET iron-particle radiation (Fe)-induced hematopoietic toxicity in Trp53-heterozygous mice. The results showed that CRIPS alone could hardly induce significant alteration in hematological parameters (peripheral hemogram and micronucleated erythrocytes in bone marrow) while concurrent exposure caused elevated genotoxicity measured as micronucleus incidence in erythrocytes. Particularly, exposure to either CRISP or Fe-particle radiation at a low dose (0.1 Gy) did not induce a marked increase in the micronucleus incidence; however, concurrent exposure caused a significantly higher increase in the micronucleus incidence. These findings indicated that CRIPS could enhance the deleterious effects of high-LET radiation, particularly at a low dose, on the hematopoietic toxicity in Trp53-heterozygous mice.
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DOI：
10.1073/pnas.1203930109
发表时间：
2012-05-01
影响因子：
11.1
作者：
Feng, Zhaohui;Liu, Lianxin;Hu, Wenwei
通讯作者：
Hu, Wenwei
影响因子：
5.1
作者：
Crucian B;Stowe RP;Mehta S;Quiriarte H;Pierson D;Sams C
通讯作者：
Sams C
影响因子：
--
作者：
Crucian, Brian E.;Stowe, Raymond P.;Sams, Clarence F.
通讯作者：
Sams, Clarence F.
影响因子：
4
作者：
Buchheim, Judith-Irina;Matzel, Sandra;Chouker, Alexander
通讯作者：
Chouker, Alexander
影响因子：
3.3
作者：
Forlenza, MJ;Latimer, JJ;Baum, A
通讯作者：
Baum, A