Alterations in adaptive immunity persist during long-duration spaceflight.
Alterations in adaptive immunity persist during long-duration spaceflight.
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DOI：
10.1038/npjmgrav.2015.13
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发表时间：
2015
期刊：
影响因子：
5.1
通讯作者：
Sams C
中科院分区：
文献类型：
--
作者：
Crucian B;Stowe RP;Mehta S;Quiriarte H;Pierson D;Sams C
目前尚不清楚在长时间的航天飞行中，免疫系统是否会持续变化。在这项研究中，宇航员在国际空间站(ISS)上进行了为期6个月的太空飞行，在三个时间间隔内评估了各种适应性免疫参数。评估参加6个月轨道飞行的宇航员的表型和功能免疫系统的变化。参加为期6个月的国际空间站探险的23名宇航员在飞行前、飞行中和飞行后都采集了血液。飞行中的样本在采集后48 小时内被送回地球进行立即分析。检测包括外周血白细胞分布、T细胞功能、病毒特异性免疫和有丝分裂原刺激的细胞因子产生情况。在飞行过程中，白细胞亚群发生了重新分布，包括白细胞(WBC)计数升高和CD8+T细胞成熟的改变。在6个月的航天飞行期间，总体T细胞功能(包括CD4+和CD8+)的下降持续存在，有丝分裂原之间的不同反应表明激活阈值发生了移动。着陆后，能够产生IL-2的CD4+T细胞的百分比被抑制。有丝分裂原刺激的干扰素γ、IL-10、IL-5、肿瘤坏死因子α和IL-6的产生在航天期间持续显著减少。在脂多糖刺激下，飞行过程中IL-10的产生减少，而IL-8的产生增加。数据表明，在长时间的航天飞行中，免疫变化持续存在。在没有适当对策的情况下，这种现象有可能增加机组人员在探索级深空任务中的具体临床风险。
It is currently unknown whether immune system alterations persist during long-duration spaceflight. In this study various adaptive immune parameters were assessed in astronauts at three intervals during 6-month spaceflight on board the International Space Station (ISS). To assess phenotypic and functional immune system alterations in astronauts participating in 6-month orbital spaceflight. Blood was collected before, during, and after flight from 23 astronauts participating in 6-month ISS expeditions. In-flight samples were returned to Earth within 48 h of collection for immediate analysis. Assays included peripheral leukocyte distribution, T-cell function, virus-specific immunity, and mitogen-stimulated cytokine production profiles. Redistribution of leukocyte subsets occurred during flight, including an elevated white blood cell (WBC) count and alterations in CD8+ T-cell maturation. A reduction in general T-cell function (both CD4+ and CD8+) persisted for the duration of the 6-month spaceflights, with differential responses between mitogens suggesting an activation threshold shift. The percentage of CD4+ T cells capable of producing IL-2 was depressed after landing. Significant reductions in mitogen-stimulated production of IFNγ, IL-10, IL-5, TNFα, and IL-6 persisted during spaceflight. Following lipopolysaccharide (LPS) stimulation, production of IL-10 was reduced, whereas IL-8 production was increased during flight. The data indicated that immune alterations persist during long-duration spaceflight. This phenomenon, in the absence of appropriate countermeasures, has the potential to increase specific clinical risks for crewmembers during exploration-class deep space missions.
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影响因子：
15.1
作者：
Pierson, DL;Stowe, RP;Mehta, SK
通讯作者：
Mehta, SK
影响因子：
15.1
作者：
Mehta, S. K.;Laudenslager, M. L.;Pierson, D. L.
通讯作者：
Pierson, D. L.
影响因子：
15.1
作者：
Kaur, I;Simons, ER;Pierson, DL
通讯作者：
Pierson, DL
影响因子：
3.8
作者：
Mehta, S. K.;Crucian, B. E.;Pierson, D. L.
通讯作者：
Pierson, D. L.
影响因子：
--
作者：
Crucian, Brian E.;Stowe, Raymond P.;Sams, Clarence F.
通讯作者：
Sams, Clarence F.