Evidence of significant central fatigue in patients with cancer-related fatigue during repetitive elbow flexions till perceived exhaustion.
Evidence of significant central fatigue in patients with cancer-related fatigue during repetitive elbow flexions till perceived exhaustion.
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DOI：
10.1371/journal.pone.0115370
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yue GH
中科院分区：
文献类型：
--
作者：
Cai B;Allexandre D;Rajagopalan V;Jiang Z;Siemionow V;Ranganathan VK;Davis MP;Walsh D;Dai K;Yue GH
研究癌症相关性疲劳（CRF）患者间歇性运动任务引起的疲劳是中枢性的还是外周性的。10例CRF患者（未接受化疗和放疗）和14例年龄匹配的健康对照者入选。参与者完成了简短的疲劳量表（BFI），并进行了疲劳任务，包括间歇性屈肘收缩在次最大（40%最大自愿收缩）的强度，直到自我感觉疲惫。通过施加到肱二头肌的电刺激引起抽搐力。使用定义为IMT后抽搐力与IMT前抽搐力的抽搐力比（TFratio）评估外周（肌肉）与中枢对间歇性运动任务（IMT）诱导的疲劳的贡献的相对程度。还量化了每例受试者进行的试验（间歇性收缩）总数和所有试验的总持续时间。CRF患者的BFI评分高于对照组（p<0.001），表明CRF患者比对照组有更强的疲劳感。与对照组受试者相比，CRF组受试者的试验次数显著减少，试验总持续时间显著缩短（p<0.05）。CRF组TF比值（0.81±0.05）高于对照组（0.62±0.05）（P<0.05），提示CRF患者在感觉疲劳时的肌肉（外周）疲劳程度显著降低。与先前的研究结果一致，疲劳下次最大持续收缩，我们的研究结果表明，运动疲劳在CRF是中央比周边起源在IMT。CRF患者的显著中枢疲劳限制了他们延长运动表现的能力。
To investigate whether fatigue induced by an intermittent motor task in patients with cancer-related fatigue (CRF) is more central or peripheral. Ten patients with CRF who were off chemo and radiation therapies and 14 age-matched healthy controls were enrolled. Participants completed a Brief Fatigue Inventory (BFI) and performed a fatigue task consisting of intermittent elbow-flexion contractions at submaximal (40% maximal voluntary contraction) intensity till self-perceived exhaustion. Twitch force was elicited by an electrical stimulation applied to the biceps brachii muscle. The relative degree of peripheral (muscle) vs. central contribution to fatigue induced by the intermittent motor task (IMT) was assessed using twitch force ratio (TFratio) defined as post IMT twitch force to pre IMT twitch force. The total number of trials (intermittent contractions) and total duration of all trials performed by each subject were also quantified. BFI scores were higher (p<0.001) in CRF than controls, indicating greater feeling of fatigue in CRF patients than controls. A significantly smaller number of trials and shorter total duration of the trials (p<0.05) were observed in CRF than control participants. The TFratio (0.81±0.05) in CRF was higher (p<0.05) compared with that of controls (0.62±0.05), suggesting CRF patients experienced a significantly lower degree of muscle (peripheral) fatigue at the time of perceived exhaustion. Consistent with prior findings for fatigue under submaximal sustained contraction, our results indicate that motor fatigue in CRF is more of central than peripheral origin during IMT. Significant central fatigue in CRF patients limits their ability to prolong motor performance.
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影响因子：
3.4
作者：
BIGLANDRITCHIE, B;WOODS, JJ
通讯作者：
WOODS, JJ
影响因子：
3.4
作者：
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影响因子：
2
作者：
Di Lazzaro, V;Oliviero, A;Rothwell, JC
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Rothwell, JC
影响因子：
3.3
作者：
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影响因子：
3.1
作者：
Morrow, GR;Andrews, PLR;Matteson, S
通讯作者：
Matteson, S