Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection.
Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection.
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DOI：
10.1093/cercor/bhp097
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Baxter MG
中科院分区：
文献类型：
--
作者：
Browning PG;Gaffan D;Croxson PL;Baxter MG
为了研究灵长类动物视觉记忆中胆碱能参与的一般性，我们训练猕猴无论是在现场学习任务的对象或延迟非匹配样本（DNMS）。每只猴子接受免疫毒素ME20.4-皂草素注射或盐水注射作为对照的颞下皮质（包括内嗅皮质和嗅周皮质）的选择性胆碱能耗竭，并在术后重新测试。颞下皮层的胆碱能耗竭对这两项任务都没有影响。每只猴子然后接受穹窿横切，因为以前的研究表明，颞叶皮层的多次断开可以产生记忆的协同损伤。穹窿横断轻度受损的场景学习的猴子接受了盐水注射，但严重受损的场景学习的猴子接受了下颞叶皮质胆碱能损伤。在进行DNMS的猴子中未观察到这种协同效应。这些发现证实了在猕猴模型的情节记忆之间的连接进行穹窿和胆碱能输入颞下皮层的协同作用。他们支持的概念，即记忆功能挖掘场景学习和DNMS具有可分离的神经基板。最后，在这项研究中，颞下皮层的胆碱能耗竭似乎不足以损害依赖于完整颞下皮层的记忆功能。
To examine the generality of cholinergic involvement in visual memory in primates, we trained macaque monkeys either on an object-in-place scene learning task or in delayed nonmatching-to-sample (DNMS). Each monkey received either selective cholinergic depletion of inferotemporal cortex (including the entorhinal cortex and perirhinal cortex) with injections of the immunotoxin ME20.4-saporin or saline injections as a control and was postoperatively retested. Cholinergic depletion of inferotemporal cortex was without effect on either task. Each monkey then received fornix transection because previous studies have shown that multiple disconnections of temporal cortex can produce synergistic impairments in memory. Fornix transection mildly impaired scene learning in monkeys that had received saline injections but severely impaired scene learning in monkeys that had received cholinergic lesions of inferotemporal cortex. This synergistic effect was not seen in monkeys performing DNMS. These findings confirm a synergistic interaction in a macaque monkey model of episodic memory between connections carried by the fornix and cholinergic input to the inferotemporal cortex. They support the notion that the mnemonic functions tapped by scene learning and DNMS have dissociable neural substrates. Finally, cholinergic depletion of inferotemporal cortex, in this study, appears insufficient to impair memory functions dependent on an intact inferotemporal cortex.
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影响因子：
5.3
作者：
Baxter, Mark G.;Gaffan, David;Mitchell, Anna S.
通讯作者：
Mitchell, Anna S.
影响因子：
5.3
作者：
Charles, DP;Gaffan, D;Buckley, MJ
通讯作者：
Buckley, MJ
影响因子：
5.3
作者：
MEUNIER, M;BACHEVALIER, J;MURRAY, EA
通讯作者：
MURRAY, EA
影响因子：
3.7
作者：
Easton, A;Ridley, RM;Gaffan, D
通讯作者：
Gaffan, D
影响因子：
1.9
作者：
Baxter, MG;Bucci, DJ;Gallagher, M
通讯作者：
Gallagher, M