Functional localization within the prefrontal cortex: missing the forest for the trees?
Functional localization within the prefrontal cortex: missing the forest for the trees?
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DOI:
10.1016/j.tins.2010.08.001
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发表时间:
2010-12
影响因子:
15.9
通讯作者:
Baxter, Mark G.
中科院分区:
文献类型:
--
作者:
Wilson, Charles R. E.;Gaffan, David;Browning, Philip G. F.;Baxter, Mark G.
Anatomical and functional studies of the prefrontal cortex (PFC) have identified multiple PFC subregions. We argue that the PFC is involved in cognitive functions exceeding the sum of specific functions attributed to its subregions. These can be revealed either by lesions of the whole PFC, or more specifically by selective disconnection of the PFC from certain types of information (for example, visual) allowing the investigation of PFC function in toto. Recent studies in macaque monkeys using the latter approach lead to a second conclusion: that the PFC, as a whole, could be fundamentally specialized for representing events that are extended in time. The representation of temporally complex events might underlie PFC involvement in general intelligence, decision-making, and executive function.
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影响因子:
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影响因子:
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