Functional localization within the prefrontal cortex: missing the forest for the trees?

Functional localization within the prefrontal cortex: missing the forest for the trees?
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DOI:
10.1016/j.tins.2010.08.001
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发表时间:
2010-12
影响因子:
15.9
通讯作者:
Baxter, Mark G.
Baxter, Mark G.
中科院分区:
医学1区
文献类型:
--
作者:
Wilson, Charles R. E.;Gaffan, David;Browning, Philip G. F.;Baxter, Mark G.

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对前额叶皮层(PFC)的解剖和功能研究已经确定了多个PFC子区域。我们认为,PFC是参与认知功能的总和超过特定的功能归因于其分区。这些可以通过整个PFC的病变来揭示,或者更具体地说,通过选择性地断开PFC与某些类型的信息(例如,视觉)的连接来研究PFC的整体功能。最近对猕猴的研究使用后一种方法得出了第二个结论:PFC作为一个整体,可以从根本上专门用于表示时间上延长的事件。对时间复杂事件的表征可能是PFC参与一般智力、决策和执行功能的基础。
Anatomical and functional studies of the prefrontal cortex (PFC) have identified multiple PFC subregions. We argue that the PFC is involved in cognitive functions exceeding the sum of specific functions attributed to its subregions. These can be revealed either by lesions of the whole PFC, or more specifically by selective disconnection of the PFC from certain types of information (for example, visual) allowing the investigation of PFC function in toto. Recent studies in macaque monkeys using the latter approach lead to a second conclusion: that the PFC, as a whole, could be fundamentally specialized for representing events that are extended in time. The representation of temporally complex events might underlie PFC involvement in general intelligence, decision-making, and executive function.
DOI: 10.1002/hipo.450050604
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