Science-in-brief: What is needed to prevent tendon injury in equine athletes? A conversation between researchers and industry stakeholders.
Science-in-brief: What is needed to prevent tendon injury in equine athletes? A conversation between researchers and industry stakeholders.
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科学简述：预防马运动员肌腱损伤需要什么？
DOI：
10.1111/evj.12269
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发表时间：
2014
影响因子：
2.2
通讯作者：
Rich T
中科院分区：
文献类型：
--
作者：
Rich T
浅表指屈肌腱（SDFT）损伤影响了多达30%的纯种赛马和其他高水平马运动员，并且与运动和年龄相关;高发病率，长时间失业，高退休率和动物福利影响是马行业持续存在的重大问题[1，2]。SDFT是高效高速运动所必需的储能结构，具有狭窄的机械安全裕度。我们对病理生理学的理解已经有了很大的进步，但预防措施还没有开发出来。大多数损伤发生在运动活动期间，在不确定时期的基质微损伤积累之后，肌腱成纤维细胞和其他内源性细胞群体不能修复（并且可能直接促成）。由于肌腱是一种愈合缓慢且再生不良的组织，因此，检测和/或预防病变的早期阶段可能比改善治疗效果更好。该研讨会于2012年10月在英国格拉斯哥大学举行，来自不同学科的重要科学家团队参加了研讨会。（包括细胞生物学、病理学、生物工程学和物理学）以及行业终端用户，包括兽医和培训师。我们特别关注纯种赛马和正常和受伤肌腱的细胞生物学。该讲习班由生物技术和生物科学研究理事会在国际讲习班计划下资助。
Superficial digital flexor tendon (SDFT) injury affects up to 30% of Thoroughbred racehorses and other high-level equine athletes and is both exercise and age related; high incidence, prolonged periods out of work, high retirement rates and animal welfare implications are continuing significant problems for equine industries [1, 2]. The SDFT is an energy-storing structure essential for efficient high-speed locomotion, with narrow mechanical safety margins. Our understanding of pathophysiology has advanced significantly, but preventative measures have not been developed. Most injuries occur during athletic activity following undefined periods of matrix microdamage accumulation that is not repaired (and possibly directly contributed to) by tendon fibroblasts and other endogenous cellular populations. Detection and/or prevention of the earliest phases of pathology are likely to have a greater effect than improvements in therapy, given that tendon is a slowly healing and poorly regenerative tissue.This workshop was held in October 2012 at the University of Glasgow, UK to bring a key group of scientists from different disciplines (including cell biology, pathology, bioengineering and physics) together with industry end-users, including veterinarians and trainers. We had a particular focus on the Thoroughbred racehorse and the cell biology of normal and injured tendons. The workshop was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) under the International Workshops scheme.
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