Initial clinical test of a breast-PET scanner.
Initial clinical test of a breast-PET scanner.
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DOI：
10.1111/j.1754-9485.2010.02230.x
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发表时间：
2011-02
影响因子：
1.6
通讯作者：
Marano GD
中科院分区：
文献类型：
--
作者：
Raylman RR;Abraham J;Hazard H;Koren C;Filburn S;Schreiman JS;Kurian S;Majewski S;Marano GD
这项初步临床研究的目的是在一小组选定的受试者中测试一种新的正电子发射/断层扫描成像仪和活检系统（PEM/PET），以评估其临床成像能力。具体来说，这项研究的主要任务是确定新系统是否可以成功地用于生成已知乳腺癌的图像，并将其与标准技术获得的图像进行比较。PEM/PET系统由位于患者扫描床下方的两对旋转辐射探测器组成。扫描仪在所有三个维度上的空间分辨率约为2 mm。受试者包括5名被诊断为局部晚期乳腺癌的患者，年龄在40至55岁之间，计划进行治疗前常规全身PET成像（使用F-18氟脱氧葡萄糖（FDG））。原发病灶直径至少2 cm。来自PEM/PET系统的图像证明，该系统能够识别一些在标准乳房X线照片中不可见的病变。此外，虽然本研究中成像的相对较大的病变均通过标准全身PET/CT扫描仪可视化，但使用PEM/PET系统可以更好地定义肿瘤的一些形态（例如导管浸润）。值得注意的是，这些图像是在标准全身PET扫描后立即获得的。新PEM/PET系统的初步测试表明，与标准方法相比，新系统能够生成高质量的乳房PET图像。
The goal of this initial clinical study was to test a new positron emission/tomography imager and biopsy system (PEM/PET) in a small group of selected subjects to assess its clinical imaging capabilities. Specifically, the main task of this study is to determine whether the new system can successfully be used to produce images of known breast cancer and compare them to those acquired by standard techniques. The PEM/PET system consists of two pairs of rotating radiation detectors located beneath a patient table. The scanner has a spatial resolution of ~2 mm in all three dimensions. The subjects consisted of five patients diagnosed with locally advanced breast cancer ranging in age from 40 to 55 years old scheduled for pre-treatment, conventional whole body PET imaging with F-18 Fluorodeoxyglucose (FDG). The primary lesions were at least 2 cm in diameter. The images from the PEM/PET system demonstrated that this system is capable of identifying some lesions not visible in standard mammograms. Furthermore, while the relatively large lesions imaged in this study where all visualised by a standard whole body PET/CT scanner, some of the morphology of the tumours (ductal infiltration, for example) was better defined with the PEM/PET system. Significantly, these images were obtained immediately following a standard whole body PET scan. The initial testing of the new PEM/PET system demonstrated that the new system is capable of producing good quality breast-PET images compared standard methods.
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