Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth
Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth
复制标题
脂联素多态性与脐带血脂联素浓度和子宫内生长的关系
DOI：
10.1038/jhg.2011.134
复制
发表时间：
2012
期刊：
影响因子：
3.5
通讯作者：
Noguchi E
中科院分区：
文献类型：
--
作者：
Saito M;Kamoda T;Nishimura K;Miyazono Y;Kanai Y;Kato Y;Iwabuchi A;Fukushima H;Hamada H;Arinami T;Sumazaki R;Noguchi E
为了评估脂联素基因（ADIPOQ）多态性是否与胎儿宫内生长和脐带血脂联素相关，我们调查了8个单核苷酸多态性，（SNP; rs182052，rs710445，rs16861205，rs12495941，rs1501299，rs3774261，rs 2082940和rs 266729）在ADIPOQ和出生体重和脐带血脂联素中的作用。我们发现，携带rs 266729 G等位基因的新生儿的出生体重sd评分显著高于C等位基因纯合子（CC：-0.06 ±0.75 vs CG：0.20±0.64 vs GG：0.07±0.78; P= 1.65× 10− 3，校正P= 9.90× 10− 3）。然而，在校正脐带血脂联素后，这种差异不显著（P= 0.04，校正后P= 0.26）。rs 266729 SNP与脐带血脂联素密切相关; rs 266729 GG新生儿的脂联素水平最高（CC：34.1±20.2 vs CG：44.3±26.1 vs GG：54.1±36.7 μg ml-1，P= 2.80× 10− 9，校正后P= 1.68× 10− 8）。在校正出生体重sd评分后，这种相关性仍然存在（P= 6.63× 10− 8，校正后P= 3.98× 10− 7）。我们的研究结果表明ADIPOQ中rs 266729 SNP对出生体重的影响可能依赖于循环脂联素。
To assess whether adiponectin gene (ADIPOQ) polymorphism is associated with intrauterine fetal growth and cord blood adiponectin, we investigated eight single-nucleotide polymorphisms (SNPs; rs182052, rs710445, rs16861205, rs12495941, rs1501299, rs3774261, rs2082940 and rs266729) in ADIPOQ and birth weight and cord blood adiponectin in 526 healthy neonates. We found that the neonates carrying the G allele of rs266729 had a significantly greater birth weight sd score than those homozygous for the C allele (CC:− 0.06±0.75 versus CG: 0.20±0.64 versus GG: 0.07±0.78; P= 1.65× 10− 3, adjusted P= 9.90× 10− 3). However, this difference was not significant after adjustment for cord blood adiponectin (P= 0.04, adjusted P= 0.26). The rs266729 SNP was strongly associated with cord blood adiponectin; neonates with rs266729 GG had the highest adiponectin (CC: 34.1±20.2 versus CG: 44.3±26.1 versus GG: 54.1±36.7 μg ml–1, P= 2.80× 10− 9, adjusted P= 1.68× 10− 8). This association remained after adjustment for birth weight sd score (P= 6.63× 10− 8, adjusted P= 3.98× 10− 7). Our results suggest that the influence of the rs266729 SNP in ADIPOQ on birth weight may be dependent on circulating adiponectin.
登录
查看更多内容
脂联素多态性、脐带血脂联素水平和身体成分。
影响因子：
14.2
作者：
D. Rothenbacher;A. Nieters;M. Weyermann;H. Brenner
通讯作者：
H. Brenner
影响因子：
16.2
作者：
Lindsay, RS;Walker, JD;Johnstone, FD
通讯作者：
Johnstone, FD
影响因子：
2.5
作者：
FOWDEN, AL
通讯作者：
FOWDEN, AL
影响因子：
5.8
作者：
Bueno, Ana Carolina;Espineira, Aniette R.;Antonini, Sonir R.
通讯作者：
Antonini, Sonir R.
通过直肠超声检查和日本黑牛硫酸雌酮血浆浓度描绘的胎儿生长曲线。
DOI：
--
发表时间：
2010
期刊：
Bulletin of the Faculty of Agriculture, Miyazaki University
影响因子：
--
作者：
Y. Mine;K. Henmi;I. Kobayashi;G. Kitahara;S. Kamimura
通讯作者：
S. Kamimura