Aerosol transmission, an indispensable route of COVID-19 spread: case study of a department-store cluster.
Aerosol transmission, an indispensable route of COVID-19 spread: case study of a department-store cluster.
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DOI：
10.1007/s11783-021-1386-6
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发表时间：
2021
影响因子：
6.4
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Jiang G;Wang C;Song L;Wang X;Zhou Y;Fei C;Liu H
COVID-19患者在全球范围内大规模爆发，导致全球范围内的广泛担忧。弄清楚COVID-19的传播途径对于控制进一步传播是必要的。我们分析了宝坻百货（中国）43名患者的数据，以补充COVID-19在聚集性疫情中的传播途径和流行病学特征。估计孵育中位数持续5.95天（2-13天）。76.3%的患者发病后立即就医。发病至入院及确诊的中位时间分别为3.96天（0-14）和5.58天（1-21）。由于暴发地点的特殊性，不同聚集性病例的患者可能表现出独特的流行病学特征。SRAS-CoV-2可通过患者呼吸道活动释放到周围空气中，并可长时间存在，便于长途运输。SRAS-CoV-2 RNA在隔离病房、普通病房、室外、卫生间、走廊、拥挤的公共区域等不同场所的气溶胶中均可检测到。分析了影响SARS冠状病毒在气溶胶中传播的环境因素，发现温度、空气湿度、通风量和灭活剂（臭氧）含量对SARS冠状病毒在气溶胶中的传播有重要影响。对于病例2 ~ 6、10、13、16、17、18、20、23的感染途径，通过分析其在宝坻百货大楼的暴露史和环境条件，我们认为气溶胶传播起了重要作用。当环境因素适宜时，在某些聚集性病例中可能发生气溶胶传播，它是COVID-19传播不可或缺的途径。
Patients with COVID-19 have revealed a massive outbreak around the world, leading to widespread concerns in global scope. Figuring out the transmission route of COVID-19 is necessary to control further spread. We analyzed the data of 43 patients in Baodi Department Store (China) to supplement the transmission route and epidemiological characteristics of COVID-19 in a cluster outbreak. Incubation median was estimated to endure 5.95 days (2–13 days). Almost 76.3% of patients sought medical attention immediately uponillness onset. The median period ofillness onsetto hospitalization and confirmation were 3.96 days (0–14) and 5.58 days (1–21), respectively. Patients with different cluster case could demonstrate unique epidemiological characteristics due to the particularity of outbreak sites. SRAS-CoV-2 can be released into the surrounding air through patient’s respiratory tract activities, and can exist for a long time for long-distance transportation. SRAS-CoV-2 RNA can be detected in aerosol in different sites, including isolation ward, general ward, outdoor, toilet, hallway, and crowded public area. Environmental factors influencing were analyzed and indicated that the SARS-CoV-2 transportation in aerosol was dependent on temperature, air humidity, ventilation rate and inactivating chemicals (ozone) content. As for the infection route of case numbers 2 to 6, 10, 13, 16, 17, 18, 20 and 23, we believe that aerosol transmission played a significant role in analyzing their exposure history and environmental conditions in Baodi Department Store. Aerosol transmission could occur in some cluster cases when the environmental factors are suitable, and it is an indispensable route of COVID-19 spread.
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影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
6.7
作者：
Milton, Donald K.;Fabian, M. Patricia;McDevitt, James J.
通讯作者：
McDevitt, James J.
影响因子：
168.9
作者：
Chan, Jasper Fuk-Woo;Yuan, Shuofeng;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
3.7
作者：
Fabian, Patricia;McDevitt, James J.;DeHaan, Wesley H.;Fung, Rita O. P.;Cowling, Benjamin J.;Chan, Kwok Hung;Leung, Gabriel M.;Milton, Donald K.
通讯作者：
Milton, Donald K.
DOI：
10.1164/rccm.200306-760oc
发表时间：
2004-06-01
影响因子：
24.7
作者：
Myatt, TA;Johnston, SL;Milton, DK
通讯作者：
Milton, DK