Role of CD5+ B-1 cells in EAE pathogenesis.
Role of CD5+ B-1 cells in EAE pathogenesis.
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DOI：
10.1080/08916930801890280
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发表时间：
2008-08
期刊：
影响因子：
3.5
通讯作者：
Fujinami RS
中科院分区：
文献类型：
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作者：
Peterson LK;Tsunoda I;Fujinami RS
Hybridoma cell lines producing natural autoantibodies (NAA), generated from A.SW mice with progressive experimental autoimmune encephalomyelitis (P-EAE), have been shown to cause demyelination and renal pathology when injected into naïve mice. To investigate the relative contribution of these antibodies to disease pathogenesis, B-1 cells, the major producers of NAA, were depleted by hypotonic shock. Depletion of B-1 cells during the effector phase of EAE significantly decreased the severity of demyelination and overall pathology in the brain. There was also a decreased incidence of P-EAE and a decrease in clinical score. Depletion during the induction phase of the disease resulted in an increase in the incidence of P-EAE and in the clinical score. Overall, B-1 cells were found to modulate EAE pathogenesis.
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DOI：
10.1084/jem.157.1.202
发表时间：
1983-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hayakawa K;Hardy RR;Parks DR;Herzenberg LA
通讯作者：
Herzenberg LA
影响因子：
5.4
作者：
MARCOS, MAR;HUETZ, F;COUTINHO, A
通讯作者：
COUTINHO, A
影响因子：
3.3
作者：
CORREALE, J;MIX, E;LINK, H
通讯作者：
LINK, H
影响因子：
4.4
作者：
MURAKAMI, M;YOSHIOKA, H;HONJO, T
通讯作者：
HONJO, T
影响因子：
--
作者：
PLATERZYBERK, C;MAINI, RN;JANOSSY, G
通讯作者：
JANOSSY, G