Multifaceted roles for lipids in viral infection.

Multifaceted roles for lipids in viral infection.
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DOI:
10.1016/j.tim.2011.03.007
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发表时间:
2011-07
影响因子:
15.9
通讯作者:
Randall G
Randall G
中科院分区:
生物学1区
文献类型:
--
作者:
Heaton NS;Randall G

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病毒已经进化出与宿主细胞复杂而动态的相互作用。近年来,我们已经深入了解宿主脂质在病毒生命周期中的作用。特别是,病毒以脂质信号、合成和代谢为目标,将宿主细胞重塑为其复制的最佳环境。这篇综述强调了来自不同病毒的例子,说明了这些不同的病毒-脂质相互作用的重要性。
Viruses have evolved complex and dynamic interactions with their host cell. In recent years we have gained insight into the expanding roles for host lipids in the virus life cycle. In particular, viruses target lipid signaling, synthesis, and metabolism to remodel their host cells into an optimal environment for their replication. This review highlights examples from different viruses that illustrate the importance of these diverse virus–lipid interactions.
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