Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.
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DOI：
10.1038/nrmicro.2016.193
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发表时间：
2017-02-27
期刊：
影响因子：
--
通讯作者：
Gilbert IH
中科院分区：
文献类型：
--
作者：
Field MC;Horn D;Fairlamb AH;Ferguson MA;Gray DW;Read KD;De Rycker M;Torrie LS;Wyatt PG;Wyllie S;Gilbert IH
世界卫生组织将非洲人类锥虫病、恰加斯病和利什曼病视为被忽视的热带疾病。这些疾病是由寄生锥虫引起的，其严重程度从轻微的自愈到几乎总是致命的不等。近几十年来，公共卫生进步已大大减少了这些疾病的影响，但仅靠这一进步并不能消除这些疾病。 Here we discuss why new drugs against trypanosomatids are needed, approaches that are under investigation to develop new drugs and why the drug discovery pipeline remains essentially unfilled.此外，我们还考虑了药物发现策略的重要挑战以及可以解决这些挑战的新技术。 The combination of new drugs, new technologies and public health initiatives are essential for the management and hopefully eventual elimination of trypanosomatid diseases from the human population.
The World Health Organization recognizes human African trypanosomiasis, Chagas’ disease and the leishmaniases as neglected tropical diseases. These diseases are caused by parasitic trypanosomatids and range in severity from mild and self-curing to near invariably fatal. Public health advances have substantially decreased the impact of these diseases in recent decades, but alone will not eliminate these diseases. Here we discuss why new drugs against trypanosomatids are needed, approaches that are under investigation to develop new drugs and why the drug discovery pipeline remains essentially unfilled. Additionally, we consider the important challenges to drug discovery strategies and the new technologies that can address them. The combination of new drugs, new technologies and public health initiatives are essential for the management and hopefully eventual elimination of trypanosomatid diseases from the human population.
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影响因子：
64.5
作者：
Akiyoshi B;Gull K
通讯作者：
Gull K
影响因子：
7.3
作者：
Brand, Stephen;Cleghorn, Laura A. T.;McElroy, Stuart P.;Robinson, David A.;Smith, Victoria C.;Hallyburton, Irene;Harrison, Justin R.;Norcross, Neil R.;Spinks, Daniel;Bayliss, Tracy;Norval, Suzanne;Stojanovski, Laste;Torrie, Leah S.;Frearson, Julie A.;Brenk, Ruth;Fairlamb, Alan H.;Ferguson, Michael A. J.;Read, Kevin D.;Wyatt, Paul G.;Gilbert, Ian H.
通讯作者：
Gilbert, Ian H.
影响因子：
4.1
作者：
Bernardes, L. S. C.;Zani, C. L.;Carvalho, I.
通讯作者：
Carvalho, I.
影响因子：
6.4
作者：
Bustamante, Juan M.;Craft, Julie M.;Tarleton, Rick L.
通讯作者：
Tarleton, Rick L.
影响因子：
3.4
作者：
Bart JM;Cordon-Obras C;Vidal I;Reed J;Perez-Pastrana E;Cuevas L;Field MC;Carrington M;Navarro M
通讯作者：
Navarro M