Influenza a virus migration and persistence in North American wild birds.
Influenza a virus migration and persistence in North American wild birds.
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DOI：
10.1371/journal.ppat.1003570
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发表时间：
2013
期刊：
影响因子：
6.7
通讯作者：
Webster RG
中科院分区：
文献类型：
--
作者：
Bahl J;Krauss S;Kühnert D;Fourment M;Raven G;Pryor SP;Niles LJ;Danner A;Walker D;Mendenhall IH;Su YC;Dugan VG;Halpin RA;Stockwell TB;Webby RJ;Wentworth DE;Drummond AJ;Smith GJ;Webster RG
野生鸟类与人类和牲畜流感的出现有关。由于严重缺乏对不同宿主群体之间病毒运动的了解，对病毒传播和疾病出现的成功预测以及防备计划的制定受到了阻碍。因此，野鸟病毒的病毒传播模式和随后造成的风险仍然不可预测。在这里，我们分析了基因组数据，包括287个新测序的甲型禽流感病毒（AIV）样本，这些样本是在北美候鸟连续34年的系统监测期间分离出来的。我们使用贝叶斯统计框架来测试病毒迁移，种群结构和基因重组模式的假设。我们的研究结果表明，尽管特拉华湾的Charadriiformes感染率很高，但这个宿主种群似乎对北美anseformes的AIV多样性没有显著贡献。相比之下，从艾伯塔省的雁形目采集的流感病毒是北美雁形目中流行的AIV多样性的代表。虽然AIV可能在短时间内局限于特定的迁徙航线，但我们的大规模分析表明，AIV的长期持续存在与整个北美种群之间的迁徙鸟类航线无关。对长期监测数据的分析为开发对大流行防范和牲畜保护至关重要的预测模型提供了重要的见解。尽管对野生水禽（雁形目）和滨鸟（鸻形目）进行了持续的病毒学监测（1976-2009年），但对这些宿主中甲型禽流感病毒（AIV）的生态和进化动态知之甚少。对AIV数据的比较基因组分析显示，特拉华湾Charadriiformes感染的高流行率是AIV的储存库，与大多数北美anseformes的AIV样本在系统发育上不同。相比之下，从艾伯塔省的雁形目动物取样的流感病毒代表了整个北美取样的剩余AIV多样性。虽然AIV可能在短时间内局限于特定的迁徙路线，但我们的大规模分析表明，这种种群遗传结构是短暂的，AIV的长期持久性与鸟类的迁徙路线无关。这些结果表明，引入的病毒谱系最初可能局限于一条飞行路线，但可能会迁移到阿尔伯塔省等主要聚集地，随后在整个飞行路线上传播。这些对病毒运动的广义预测对于评估相关的广泛传播风险和为大流行防范监测提供信息至关重要。
Wild birds have been implicated in the emergence of human and livestock influenza. The successful prediction of viral spread and disease emergence, as well as formulation of preparedness plans have been hampered by a critical lack of knowledge of viral movements between different host populations. The patterns of viral spread and subsequent risk posed by wild bird viruses therefore remain unpredictable. Here we analyze genomic data, including 287 newly sequenced avian influenza A virus (AIV) samples isolated over a 34-year period of continuous systematic surveillance of North American migratory birds. We use a Bayesian statistical framework to test hypotheses of viral migration, population structure and patterns of genetic reassortment. Our results reveal that despite the high prevalence of Charadriiformes infected in Delaware Bay this host population does not appear to significantly contribute to the North American AIV diversity sampled in Anseriformes. In contrast, influenza viruses sampled from Anseriformes in Alberta are representative of the AIV diversity circulating in North American Anseriformes. While AIV may be restricted to specific migratory flyways over short time frames, our large-scale analysis showed that the long-term persistence of AIV was independent of bird flyways with migration between populations throughout North America. Analysis of long-term surveillance data provides vital insights to develop appropriately informed predictive models critical for pandemic preparedness and livestock protection. Despite continuous virological surveillance (1976–2009) in wild waterfowl (Anseriformes) and shorebirds (Charadriiformes), the ecological and evolutionary dynamics of avian influenza A virus (AIV) in these hosts is poorly understood. Comparative genomic analysis of AIV data revealed that the high prevalence of Charadriiformes infected in Delaware Bay is a reservoir of AIV that is phylogenetically distinct from AIV sampled from most North American Anseriformes. In contrast, influenza viruses sampled from Anseriformes in Alberta are representative of the remaining AIV diversity sampled across North America. While AIV may be restricted to specific migratory flyways over short time frames, our large-scale analysis showed that this population genetic structure was transient and the long-term persistence of AIV was independent of bird flyways. These results suggest an introduced virus lineage may initially be restricted to one flyway, but migration to a major congregation site such as Alberta could occur followed by subsequent spread across flyways. These generalized predictions for virus movement will be critical to assess the associated risk for widespread diffusion and inform surveillance for pandemic preparedness.
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迁徙鸟类中的流感和洲际病毒交换有限的证据。
影响因子：
6.7
作者：
Krauss, Scott;Obert, Caroline A;Franks, John;Walker, David;Jones, Kelly;Seiler, Patrick;Niles, Larry;Pryor, S Paul;Obenauer, John C;Naeve, Clayton W;Widjaja, Linda;Webby, Richard J;Webster, Robert G
通讯作者：
Webster, Robert G
阿拉斯加野生迁徙鸟类中流感A病毒的流行：在洲际飞行道的十字路口检测模式。
影响因子：
4.8
作者：
Ip, Hon S.;Flint, Paul L.;Franson, J. Christian;Dusek, Robert J.;Derksen, Dirk V.;Gill, Robert E., Jr.;Ely, Craig R.;Pearce, John M.;Lanctot, Richard B.;Matsuoka, Steven M.;Irons, David B.;Fischer, Julian B.;Oates, Russell M.;Petersen, Margaret R.;Fondell, Thomas F.;Rocque, Deborah A.;Pedersen, Janice C.;Rothe, Thomas C.
通讯作者：
Rothe, Thomas C.
影响因子：
2.1
作者：
Hill, Nichola J.;Takekawa, John Y.;Boyce, Walter M.
通讯作者：
Boyce, Walter M.
影响因子：
11.8
作者：
Al-Azemi A;Bahl J;Al-Zenki S;Al-Shayji Y;Al-Amad S;Chen H;Guan Y;Peiris JS;Smith GJ
通讯作者：
Smith GJ
影响因子：
9.8
作者：
Drummond AJ;Ho SY;Phillips MJ;Rambaut A
通讯作者：
Rambaut A