A prognostic model for resectable acral melanoma patients on the basis of preoperative inflammatory markers
A prognostic model for resectable acral melanoma patients on the basis of preoperative inflammatory markers
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基于术前炎症标志物的可切除肢端黑色素瘤患者的预后模型
DOI：
10.1097/cmr.0000000000000365
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发表时间：
2017-06
影响因子：
2.2
通讯作者：
Zhang Xiao-Shi
中科院分区：
文献类型：
--
作者：
Wang Yao;Wen Xi-Zhi;Ba Hong-Jun;Li Dan-Dan;Ding Ya;Wang Ke-Feng;Li Jing-Jing;Zhang Xiao-Shi
肢端黑色素瘤是一种罕见疾病，但在亚洲很常见。对其预后指标的了解有限。越来越多的证据表明炎症在肢端黑色素瘤的发生和进展中起着至关重要的作用。我们根据术前炎症标志物开发了一种新型预后模型，并在一组患者中检查了其预后价值。这项回顾性研究纳入了2000年至2010年间在中山大学肿瘤防治中心接受根治性手术切除的232例肢端黑色素瘤患者。通过多变量 Cox 回归分析确定了显着的预测因素，并构建了基于这些变量的预后模型来预测生存。绘制卡普兰-迈耶曲线来估计总体生存率。多变量分析表明，C 反应蛋白、白蛋白/球蛋白比、年龄、乳酸脱氢酶和淋巴结阳性与生存率独立相关。分析这些变量后，我们将患者分为三个风险组。新的预后模型确定了三类具有不同预后的患者（P<0.001），并将患者预后显着分层为不同的肿瘤阶段。新预后模型的曲线下面积为0.684（95%置信区间：0.620-0.743），显着高于其他变量（P<0.001）。 C反应蛋白和白蛋白/球蛋白比率与我们研究人群的生存率独立相关，并且使用基于炎症的评分开发的预后模型可用于将患者分层为不同的风险组。因此，该模型将成为 2009 年美国癌症联合委员会对亚洲肢端黑色素瘤患者分期的宝贵补充。
Acral melanoma is a rare disease, but is common in Asia. Knowledge of its prognostic indicators is limited. Growing evidence indicates that inflammation plays a critical role in the development and progression of acral melanoma. We developed a novel prognostic model on the basis of preoperative inflammatory markers and examined its prognostic value in a cohort of patients. This retrospective study included 232 acral melanoma patients who underwent radical surgical resection between 2000 and 2010 at the Sun Yat-sen University Cancer Center. Significant predictive factors were identified by multivariate Cox regression analyses, and a prognostic model on the basis of these variables was constructed to predict survival. Kaplan–Meier curves were plotted to estimate overall survival. Multivariate analyses showed that C-reactive protein, albumin/globulin ratio, age, lactic dehydrogenase, and lymph node positivity were related independently to survival. After analyzing these variables, we classified patients into three risk groups. The new prognostic model identified three categories of patients with different prognoses (P<0.001) and significantly stratified patient prognosis into different tumor stages. The area under the curve of the new prognostic model was 0.684 (95% confidence interval: 0.620–0.743), which was significantly higher than that of the other variables (P<0.001). C-reactive protein and albumin/globulin ratio were independently related to survival in our study population and the prognostic model developed using inflammatory-based scores was useful in stratifying patients into different risk groups. Thus, this model will be a valuable complement to the 2009 American Joint Committee on Cancer staging for Asian patients with acral melanoma.
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影响因子：
4.7
作者：
Mahmoud, Fade Aziz;Rivera, Nilo I
通讯作者：
Rivera, Nilo I
影响因子：
--
作者：
Bradford, Porcia T.;Goldstein, Alisa M.;McMaster, Mary L.;Tucker, Margaret A.
通讯作者：
Tucker, Margaret A.
影响因子：
3.7
作者：
Li YJ;Li ZM;Xia Y;Huang JJ;Huang HQ;Xia ZJ;Lin TY;Li S;Cai XY;Wu-Xiao ZJ;Jiang WQ
通讯作者：
Jiang WQ
影响因子：
3.6
作者：
Schneider, Samantha L.;Ross, Andrew L.;Grichnik, James M.
通讯作者：
Grichnik, James M.
DOI：
10.47102/annals-acadmedsg.v41n1p17
发表时间：
2012-01
期刊：
Annals of the Academy of Medicine, Singapore
影响因子：
--
作者：
H. Lee;W. Chay;M. Tang;M. Chio;S. Tan
通讯作者：
H. Lee;W. Chay;M. Tang;M. Chio;S. Tan