The effect of geographic origin on the frequency of HLA antigens and their association with ageing.
The effect of geographic origin on the frequency of HLA antigens and their association with ageing.
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地理起源对 HLA 抗原频率的影响及其与衰老的关系。
DOI：
10.1046/j.1365-2370.2000.00206.x
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Ligthart,GJ
中科院分区：
文献类型：
--
作者：
Izaks,GJ;Remarque,EJ;Schreuder,GM;Westendorp,RG;Ligthart,GJ
HLA抗原与衰老之间的关系尚不清楚。在最近的一项研究中，女性的衰老与B40和DR5有关，但其他研究得出了相互矛盾的结果。然而，在所有的研究中，年轻人和老年人的样本都不是来自同一个同质人群。同质性取决于地理来源。本研究的目的是调查不同年龄组之间地理来源的差异是否可以解释B40和DR5频率的年龄相关差异。作者采用了“出生地点限制性比较”的新设计，确定了所有受试者的来源。总研究人群包括1010名25-40岁的年轻女性和660名85岁及以上的老年女性。“出生地限制比较”包括66名年轻女性和285名老年女性，她们来自同一个地理区域（荷兰莱顿）。男性没有被包括在内，因为在最近的一项研究中，男性的衰老与HLA抗原无关。在总人口中，不同出身的年轻女性B40的频率在16%到28%之间变化，DR5的频率在11%到23%之间变化。在老年妇女中也观察到类似的差异。在“出生地限制比较”中，B40的频率在年轻女性中为15%，在老年女性中为11%（差异为4%，95%置信区间为- 5至13%）。DR5的频率在年轻女性中为20%，在老年女性中为28%（差异为8%，95%可信区间为- 4至19%）。因此，在不同地理来源的人群中发现了HLA抗原频率的显著差异。因此，在衰老的遗传研究中，对目标人群的定义和确定是必要的。在这种“出生地限制比较”中，作者证实，女性的衰老与HLA - B40负相关，与HLA - DR5正相关。
The association between HLA antigens and ageing is not clear. Ageing in women was associated with B40 and DR5 in a recent study, but other studies yielded conflicting results. In none of the studies, however, did the young and elderly samples originate from the same homogeneous population. Homogeneity is dependent on geographic origin. The aim of this study was to investigate whether differences in geographic origin between age groups could explain the age‐associated differences in the frequencies of B40 and DR5. The authors used the new design of a ‘birth‐place‐restricted comparison’ in which the origin of all subjects was ascertained. The total study population comprised 1010 young women aged 25–40 years and 660 elderly women aged 85 years and older. The ‘birth‐place‐restricted comparison’ included 66 young and 285 elderly women from one geographic area (Leiden, the Netherlands). Men were not included because ageing in men was not associated with HLA antigens in a recent study. In the total population, the frequency of B40 in young women of different origin varied between 16 and 28%, and the frequency of DR5 between 11 and 23%. Similar differences were observed in the elderly women. In the ‘birth‐place‐restricted comparison’, the frequency of B40 was 15% in the young women and 11% in the elderly women (difference 4%, 95% confidence interval, −5 to 13%). The frequency of DR5 was 20% in the young women, and 28% in the elderly women (difference 8%, 95% confidence interval, −4 to 19%). Thus, marked differences in HLA antigen frequency were found between populations of various geographic origins. Definition and ascertainment of the target population are therefore necessary in genetic studies of ageing. In such a ‘birth‐place‐restricted comparison’, the authors confirmed that ageing in women was negatively associated with HLA‐B40 and positively associated with HLA‐DR5.
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