Weaning stress and gastrointestinal barrier development: Implications for lifelong gut health in pigs.
Weaning stress and gastrointestinal barrier development: Implications for lifelong gut health in pigs.
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DOI：
10.1016/j.aninu.2017.06.003
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Rajput M
中科院分区：
文献类型：
--
作者：
Moeser AJ;Pohl CS;Rajput M
胃肠道（GI）屏障在动物和人类的生存和整体健康中起着关键作用。几层屏障防御机制由上皮、免疫和肠神经系统提供。它们共同起作用以控制正常的肠道功能（例如，消化、吸收、分泌、免疫等）而同时提供了与管腔环境中的不利条件隔离的屏障。这些关键GI功能的破坏是猪中最严重GI疾病的中心病理生理机制。本综述将重点介绍猪胃肠道屏障的发育和功能特性，以及常见的早期生产应激因素（如断奶）如何改变即时和长期屏障功能和疾病易感性。具体的压力相关的病理生理机制负责驱动胃肠道屏障功能障碍引起的断奶和动物健康和性能的影响进行了讨论。
The gastrointestinal (GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions (e.g., digestion, absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease susceptibility. Specific stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed.
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