Effect of keishibukuryogan on genetic and dietary obesity models.
Effect of keishibukuryogan on genetic and dietary obesity models.
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DOI：
10.1155/2015/801291
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Hayakawa Y
中科院分区：
文献类型：
--
作者：
Gao F;Yokoyama S;Fujimoto M;Tsuneyama K;Saiki I;Shimada Y;Hayakawa Y
肥胖已被认为是多种慢性疾病最重要的危险因素之一，如糖尿病、高血压/心血管疾病、脂肪变性/肝炎和癌症。桂芝补灵丸（KBG，中国的桂芝补灵丸）是一种传统的中国/日本（汉布）药物，众所周知，它可以改善血液循环，也以其抗炎或清道夫的作用而闻名。在这项研究中，我们评估了KBG在两种不同的啮齿动物肥胖模型中的作用，这两种模型分别由遗传（SHR/NDmcr-cp大鼠模型）或饮食（高脂肪饮食诱导的小鼠肥胖模型）机制驱动。虽然对SHR大鼠和DIO小鼠模型的体成分没有显著影响，但KBG治疗显著降低了DIO小鼠的血清瘦素水平和肝脏TG水平，而在SHR大鼠模型中没有。此外，经KBG治疗的DIO小鼠肝脏脂肪沉积减少，白色脂肪组织中脂肪细胞体积减小。重要的是，我们进一步发现，在kbg处理的肝脏中，参与脂质代谢的基因下调，同时肝脏TG和胆固醇水平降低。我们目前的实验数据表明，KBG可以通过调节全身瘦素水平和/或脂质代谢来改善肥胖状况，是一种有吸引力的汉布药。
Obesity has been recognized as one of the most important risk factors for a variety of chronic diseases, such as diabetes, hypertension/cardiovascular diseases, steatosis/hepatitis, and cancer. Keishibukuryogan (KBG, Gui Zhi Fu Ling Wan in Chinese) is a traditional Chinese/Japanese (Kampo) medicine that has been known to improve blood circulation and is also known for its anti-inflammatory or scavenging effect. In this study, we evaluated the effect of KBG in two distinct rodent models of obesity driven by either a genetic (SHR/NDmcr-cp rat model) or dietary (high-fat diet-induced mouse obesity model) mechanism. Although there was no significant effect on the body composition in either the SHR rat or the DIO mouse models, KBG treatment significantly decreased the serum level of leptin and liver TG level in the DIO mouse, but not in the SHR rat model. Furthermore, a lower fat deposition in liver and a smaller size of adipocytes in white adipose tissue were observed in the DIO mice treated with KBG. Importantly, we further found downregulation of genes involved in lipid metabolism in the KBG-treated liver, along with decreased liver TG and cholesterol level. Our present data experimentally support in fact that KBG can be an attractive Kampo medicine to improve obese status through a regulation of systemic leptin level and/or lipid metabolism.
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影响因子：
3.2
作者：
Fujimoto, Makoto;Tsuneyama, Koichi;Shimada, Yutaka
通讯作者：
Shimada, Yutaka
影响因子：
7.9
作者：
Goto, H;Shimada, Y;Terasawa, K
通讯作者：
Terasawa, K
影响因子：
2.7
作者：
Yamazaki, Y;Shikamoto, Y;Morita, T
通讯作者：
Morita, T
影响因子：
3.9
作者：
Spiegelman, BM;Hu, E;Brun, R
通讯作者：
Brun, R
影响因子：
9.8
作者：
Muenzberg, Heike;Morrison, Christopher D.
通讯作者：
Morrison, Christopher D.