Tracking dynamic interactions during plaque formation.
Tracking dynamic interactions during plaque formation.
复制标题
跟踪斑块形成过程中的动态相互作用。
DOI：
10.1128/jb.01344-08
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发表时间：
2008
影响因子：
3.2
通讯作者：
Davey,MaryEllen
中科院分区：
文献类型：
--
作者：
Davey,MaryEllen
The mouth is an ecologically complex environment and host to a diverse microbial community (18, 20). Many of the microbes amass and grow between the teeth and along the gum line, resulting in formation of dental plaque. High cell density is a key characteristic of this microbial community, and plaque development is inffuenced by both cooperative and competitive interactions (12). Interactions occur through physical contact and through sensing the concentrations of extracellular compounds and signaling molecules. Communication between species may include favorable cross-feeding, competition for essential nutrients, killing through secretion of antimicrobial compounds, the production of extracellular molecules whose sole role is to inffuence gene expression, and the release of end products that broadcast metabolic activities throughout the community at the functional level (8, 13). Moreover, some or all of the interactions may occur simultaneously. Dissecting the spatial relationships between bacteria within the community and determining why juxtaposition of certain species is favorable are two primary challenges in oral biofilm research. Although complexity has made it extremely difficult to discern the full extent of interactions, in vivo accessibility makes dental plaque amenable to manipulation. In this issue of the Journal of Bacteriology, Chalmers et al.(1a) describe a novel approach for tracking the complex microbial interactions within this biofilm community. They, for the first time, conclusively demonstrate a role for specific cell-cell contact in the initial stages of plaque formation.
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影响因子：
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作者：
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DOI：
--
发表时间：
1992
期刊：
影响因子：
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作者：
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影响因子：
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