Young MSM changed temporal HIV-1 epidemic pattern in Heilongjiang Province, China.
Young MSM changed temporal HIV-1 epidemic pattern in Heilongjiang Province, China.
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DOI：
10.3389/fmicb.2022.1028383
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发表时间：
2022
影响因子：
5.2
通讯作者：
Wang, Fu-Xiang
中科院分区：
文献类型：
--
作者：
Li, Qing-Hai;Wang, Jia-Ye;Liu, Si-Yu;Zhang, Yun-Qi;Li, En-Long;Wang, Yi-Ru;Zhang, Shu-Lei;Zhao, Wen-Bo;Liu, Shu-Lin;Chen, Xiao-Hong;Wang, Fu-Xiang
中国人类免疫缺陷病毒1型（HIV-1）疫情具有流行模式地域多样性的特点。了解区域性HIV-1疫情特点，有针对性地开展防控措施。这项为期七年的横断面研究是在中国东北省份黑龙江进行的，该省的新诊断感染者每年都在快速增加，但 HIV-1 的时间流行趋势在很大程度上尚不清楚。收集了2010年至2016年黑龙江省1006名新诊断的HIV-1感染者在抗逆转录病毒治疗前的信息。 HIV-1基因型是根据病毒gag和env基因序列鉴定的。通过限制抗原亲合力测定确定近期感染。对不同人群和采样时间的中位年龄、CD4计数、分层年龄组和CD4计数组的比例以及近期HIV-1感染率进行比较分析，了解HIV-1流行的时间特征。男男性行为者（MSM）之间的同性接触是主要传播途径，CRF01_AE 是最主要的 HIV-1 基因型。 2010-2016年，HIV-1疫情呈现三个新变化：中位年龄持续下降、CD4计数超过500个/μl的病例（CD4hi病例）不成比例地扩大、近期HIV-1感染率稳步上升。 MSM 病例决定了这里 HIV-1 流行的时间趋势。年轻MSM病例（年龄<30岁）的增加是MSM病例低龄化趋势的主要贡献者。与 30 岁及以上的病例相比，这些年轻的 MSM 表现出较高的中位 CD4 计数、较高的 CD4hi 病例比例以及较高的近期 HIV-1 感染率。 CRF01_AE病毒感染的MSM主要影响MSM人群中HIV-1的流行模式。年轻MSM已成为黑龙江省HIV-1传播的新热点和易感群体。年轻MSM病例（主要是CRF01_AE感染者）数量的迅速增加，改变了这里的HIV-1流行模式。未来迫切需要采取措施预防和控制该人群中的HIV-1感染。
Human immunodeficiency virus type 1 (HIV-1) epidemic in China is featured by geographical diversity of epidemic patterns. Understanding the characteristics of regional HIV-1 epidemic allows carrying out targeted prevention and controlling measures. This seven-year cross-sectional study was conducted in Heilongjiang, one province of Northeast China, where newly diagnosed infection is fast increasing yearly, but temporal HIV-1 epidemic trend is largely unknown. Information of 1,006 newly diagnosed HIV-1-infected participants were collected before antiretroviral therapy during 2010–2016 in Heilongjiang province. HIV-1 genotype was identified based on the viral gag and env gene sequences. Recent infection was determined by Limiting-Antigen Avidity assays. Comparison analyses on the median ages, CD4 counts, proportions of stratified age groups and CD4 count groups, and rates of recent HIV-1 infection among different population and sampling times were performed to understand temporal HIV-1 epidemic features. Homosexual contact among men who have sex with men (MSM) was the main transmission route and CRF01_AE was the most dominant HIV-1 genotype. During 2010–2016, the HIV-1 epidemic showed three new changes: the median age continued to decline, the cases with a CD4 count more than 500 cells/μl (CD4hi cases) disproportionally expanded, and the recent HIV-1 infection rate steadily increased. MSM cases determined the temporal trend of HIV-1 epidemic here. Increase of young MSM cases (aged <30 years) made the main contribution to the younger age trend of MSM cases. These young MSM exhibited a higher median CD4 count, a higher proportion of CD4hi cases, and a higher rate of recent HIV-1 infection than cases aged 30 years and more. MSM infected by CRF01_AE virus mostly affected HIV-1 epidemic patterns among MSM population. Young MSM have become a new hotspot and vulnerable group for HIV-1 transmission in Heilongjiang Province, Northeast China. The rapid increase in the number of young MSM cases, mainly those with CRF01_AE infection, changed temporal HIV-1 epidemic pattern here. Measures for prevention and control of HIV-1 infection among this population are urgently needed in the future.
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关键氨基酸残基和潜在的N联糖基化位点有助于中国东北地区循环重组01_AE发病机制
影响因子：
3.8
作者：
Li, Qing-Hai;Shao, Bing;Liu, Shu-Lin
通讯作者：
Liu, Shu-Lin
影响因子：
5.4
作者：
Hemelaar, Joris;Loganathan, Shanghavie;Kirtley, Shona
通讯作者：
Kirtley, Shona
DOI：
10.1097/qad.0b013e328342ff93
发表时间：
2011-03-13
期刊：
AIDS (London, England)
影响因子：
--
作者：
Hemelaar J;Gouws E;Ghys PD;Osmanov S;WHO-UNAIDS Network for HIV Isolation and Characterisation
通讯作者：
WHO-UNAIDS Network for HIV Isolation and Characterisation
中国迅速扩展的CRF01_AE流行是由1990年代引入的HIV-1病毒的多个谱系驱动的。
DOI：
10.1097/qad.0b013e328360db2d
发表时间：
2013-07-17
期刊：
AIDS (London, England)
影响因子：
--
作者：
Feng Y;He X;Hsi JH;Li F;Li X;Wang Q;Ruan Y;Xing H;Lam TT;Pybus OG;Takebe Y;Shao Y
通讯作者：
Shao Y
中国上海最近感染的男男性行为者中 HIV-1 遗传多样性及其对基线 CD4 T 细胞和病毒载量的影响
影响因子：
3.7
作者：
Li X;Xue Y;Cheng H;Lin Y;Zhou L;Ning Z;Wang X;Yu X;Zhang W;Shen F;Zheng X;Gai J;Li X;Kang L;Nyambi P;Wang Y;Zhuang M;Pan Q;Zhuang X;Zhong P
通讯作者：
Zhong P