Mouse alopecia areata models: an array of data on mechanisms and genetics.
Mouse alopecia areata models: an array of data on mechanisms and genetics.
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小鼠斑秃模型：一系列有关机制和遗传学的数据。
DOI：
10.1046/j.1087-0024.2003.00804.x
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
KingJr,LloydE
中科院分区：
文献类型：
--
作者：
Sundberg,JohnP;KingJr,LloydE
实验室小鼠已成为大多数人类和家畜疾病的首要动物模型，它们长期以来一直是研究哺乳动物遗传学的首选模型，特别是自基因工程出现以来。通过对这些奇妙的小型哺乳动物的深入研究，已经取得了许多显着的发现，并且显然还会有更多的发现。1，2已经发现了一种斑秃（AA）小鼠模型并不奇怪，3可能还会有更多，其中一些表现出在患有该疾病的人类亚群中发现的罕见表型，如指甲畸形，甲状腺疾病，炎症性肠病，和自身免疫性多内分泌综合征14型，5许多研究小组对第一种模型，AA的成人发病形式（使用C3 H/HeJ近交系）进行了深入研究，发现了与人类AA普遍持有的观点的相似性和差异。尽管存在一些争议，但从研究这些和其他啮齿动物和家畜模型中获得了许多见解，这为AA及其治疗开辟了新的思路和讨论。
Laboratory mice have become the premier animal model for most human and domestic animal diseases, and they have long been the model of choice for studying mammalian genetics, especially since the advent of genetic engineering. Many remarkable discoveries have been made through intense study of these wonderful small mammals, and undoubtably many more will be made.1,2It is no surprise that one mouse model for alopecia areata (AA) has been found3possibly many more will be, some of which exhibit rare phenotypes found in subpopulations of humans with the disease, such as nail deformities, thyroid disease, inflammatory bowel disease, and autoimmune polyendocrine syndrome type 14,5Intense investigation by many groups into the first model, the adult onset form of AA (using the C3H/HeJ inbred strain), found similarities as well as differences with commonly held ideas concerning human AA. Regardless of some of the controversies, much insight has been gained from studying these and other rodent and domestic animal models which has opened up new ideas and discussions of AA and its treatment.
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DOI：
10.1111/1523-1747.ep12375477
发表时间：
1994
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Tobin,DJ;Orentreich,N;Fenton,DA;Bystryn,JC
通讯作者：
Bystryn,JC
影响因子：
--
作者：
Gilhar, A;Landau, M;Kalish, RS
通讯作者：
Kalish, RS
影响因子：
6.5
作者：
Gilhar, A;Landau, M;Kalish, RS
通讯作者：
Kalish, RS
C3H/HeJ 小鼠和 DEBR 大鼠的斑秃样脱发可以使用局部二苯环普酮逆转。
影响因子：
--
作者：
J. Shapiro;J. Sundberg;R. Bissonnette;K. McElwee;D. McLean;J. Carroll;R. Oliver;L. Tang;H. Lui
通讯作者：
H. Lui
影响因子：
6.5
作者：
McElwee, KJ;Boggess, D;Sundberg, JP
通讯作者：
Sundberg, JP