Extraversion is linked to volume of the orbitofrontal cortex and amygdala.
Extraversion is linked to volume of the orbitofrontal cortex and amygdala.
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DOI：
10.1371/journal.pone.0028421
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
van der Wee NJ
中科院分区：
文献类型：
--
作者：
Cremers H;van Tol MJ;Roelofs K;Aleman A;Zitman FG;van Buchem MA;Veltman DJ;van der Wee NJ
神经质和外向是与抑郁和焦虑症的易感性相关的人格因素，可能与情绪信息的处理和情绪状态的产生有关的大脑结构不同。到目前为止，对大脑形态的研究主要集中在神经质，这是一个主要与负面情绪有关的维度，在与个性的关联方面产生了相互矛盾的结果，部分原因是方法学问题和正在研究的可变人群样本。最近，外倾性这一主要与积极情感有关的维度，与抑郁和焦虑症的症状一再呈负相关。在本研究中，65名健康成人的高分辨率结构T1加权磁共振图像使用优化的基于体素的形态测量(VBM)方法进行处理。进行多元回归分析，以检验神经质和外倾性与前额叶和皮质下体积的相关性。眼眶前额叶和右侧杏仁核体积均与外向呈正相关。在男性(阳性)和女性(阴性)中，外倾性与前扣带回皮质的体积存在差异。神经质得分与这些大脑区域没有明显的相关性。由于外倾性被认为是发展焦虑症和抑郁症的保护因素，并与积极情绪的产生有关，目前的结果表明，在高外倾性个体中，发生情感障碍的可能性降低与通过眶前皮质和杏仁核调节情绪处理有关。
Neuroticism and extraversion are personality factors associated with the vulnerability for developing depression and anxiety disorders, and are possibly differentially related to brain structures implicated in the processing of emotional information and the generation of mood states. To date, studies on brain morphology mainly focused on neuroticism, a dimension primarily related to negative affect, yielding conflicting findings concerning the association with personality, partially due to methodological issues and variable population samples under study. Recently, extraversion, a dimension primarily related to positive affect, has been repeatedly inversely related to with symptoms of depression and anxiety disorders. In the present study, high resolution structural T1-weighted MR images of 65 healthy adults were processed using an optimized Voxel Based Morphometry (VBM) approach. Multiple regression analyses were performed to test for associations of neuroticism and extraversion with prefrontal and subcortical volumes. Orbitofrontal and right amygdala volume were both positively related to extraversion. Extraversion was differentially related to volume of the anterior cingulate cortex in males (positive) and females (negative). Neuroticism scores did not significantly correlate with these brain regions. As extraversion is regarded a protective factor for developing anxiety disorders and depression and has been related to the generation of positive affect, the present results indicate that the reduced likelihood of developing affective disorders in individuals high on extraversion is related to modulation of emotion processing through the orbitofrontal cortex and the amygdala.
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影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
7.4
作者：
Jylha, Pekka;Isometsa, Erkki
通讯作者：
Isometsa, Erkki
DOI：
10.1196/annals.1401.006
发表时间：
2007-01-01
期刊：
LINKING AFFECT TO ACTION: CRITICAL CONTRIBUTIONS OF THE ORBITOFRONTAL CORTEX
影响因子：
--
作者：
Milad, Mohammed R.;Rauch, Scott L.
通讯作者：
Rauch, Scott L.
影响因子：
56.9
作者：
Canli, T;Sivers, H;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
1.7
作者：
Omura, K;Constable, RT;Canli, T
通讯作者：
Canli, T