Involvement of BDNF Signaling Transmission from Basolateral Amygdala to Infralimbic Prefrontal Cortex in Conditioned Taste Aversion Extinction
Involvement of BDNF Signaling Transmission from Basolateral Amygdala to Infralimbic Prefrontal Cortex in Conditioned Taste Aversion Extinction
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BDNF 信号传导从基底外侧杏仁核到边缘下前额皮质的传递参与条件性味觉厌恶消退
DOI：
10.1523/jneurosci.5030-13.2014
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发表时间：
2014-05
影响因子：
5.3
通讯作者：
Chen, Zhe-Yu
中科院分区：
文献类型：
--
作者：
Yu, Hui;Wang, Yue;Kong, Liang;Chen, Zhe-Yu
脑源性神经营养因子（BDNF）及其受体原肌球蛋白相关激酶受体B （TrkB）在记忆消退中起关键作用。然而，BDNF在基于神经回路的记忆消退中的具体作用尚不完全清楚。本研究旨在探讨BDNF信号通路在大鼠条件性味觉厌恶（CTA）记忆消退中的作用。我们发现在CTA灭绝期间BDNF基因表达发生了区域特异性变化。CTA消失导致基底外侧杏仁核（BLA）和边缘下前额叶皮层（IL）中BDNF基因表达增加，而中央杏仁核（CeA）和海马（HIP）中BDNF基因表达不增加。此外，阻断BDNF信号通路或外源性微量注射BDNF到BLA或IL中可破坏或增强CTA的消失，这表明BLA和IL中的BDNF信号通路是CTA消失的必要和充分条件。有趣的是，我们发现在BLA中微量注射BDNF中和抗体可以消除IL中消失训练诱导的BDNF mRNA水平升高，反之则不能，这表明BDNF信号在消失过程中从BLA传递到IL。最后，外源BDNF在BLA中的加速消退学习也可以被IL输注BDNF中和抗体阻断，而不是相反，这表明IL而不是BLA是BDNF在CTA消退中的主要作用位点。综上所述，这些数据表明BLA-IL回路通过识别BDNF作为关键调节因子来调节CTA记忆消退。
Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase receptor B (TrkB), play a critical role in memory extinction. However, the detailed role of BDNF in memory extinction on the basis of neural circuit has not been fully understood. Here, we aim to investigate the role of BDNF signaling circuit in mediating conditioned taste aversion (CTA) memory extinction of the rats. We found region-specific changes in BDNF gene expression during CTA extinction. CTA extinction led to increased BDNF gene expression in the basolateral amygdala (BLA) and infralimbic prefrontal cortex (IL) but not in the central amygdaloid nucleus (CeA) and hippocampus (HIP). Moreover, blocking BDNF signaling or exogenous microinjection of BDNF into the BLA or IL could disrupt or enhance CTA extinction, which suggested that BDNF signaling in the BLA and IL is necessary and sufficient for CTA extinction. Interestingly, we found that microinjection of BDNF-neutralizing antibody into the BLA could abolish the extinction training-induced BDNF mRNA level increase in the IL, but not vice versa, demonstrating that BDNF signaling is transmitted from the BLA to IL during extinction. Finally, the accelerated extinction learning by infusion of exogenous BDNF in the BLA could also be blocked by IL infusion of BDNF-neutralizing antibody rather than vice versa, indicating that the IL, but not BLA, is the primary action site of BDNF in CTA extinction. Together, these data suggest that BLA-IL circuit regulates CTA memory extinction by identifying BDNF as a key regulator.
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DOI：
10.1002/neu.10323
发表时间：
2004-02-05
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Howe, CL;Mobley, WC
通讯作者：
Mobley, WC
影响因子：
3
作者：
E. Tongiorgi;M. Righi;A. Cattaneo
通讯作者：
E. Tongiorgi;M. Righi;A. Cattaneo
影响因子：
5.3
作者：
Desmedt, A;Hazvi, S;Dudai, Y
通讯作者：
Dudai, Y
影响因子：
1.7
作者：
E. Yuen;C. Howe;Yiwen Li;D. Holtzman;W. Mobley
通讯作者：
E. Yuen;C. Howe;Yiwen Li;D. Holtzman;W. Mobley
影响因子：
2.5
作者：
M. Gallo;E. Bielavská;Gabriel Roldán;J. Bureš
通讯作者：
M. Gallo;E. Bielavská;Gabriel Roldán;J. Bureš