The role of bioactive compounds on the promotion of neurite outgrowth.
The role of bioactive compounds on the promotion of neurite outgrowth.
复制标题
生物活性化合物在促进神经突生长中的作用。
DOI：
10.3390/molecules17066728
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发表时间：
2012-06-04
期刊：
影响因子：
--
通讯作者：
Choi DK
中科院分区：
文献类型：
--
作者：
More SV;Koppula S;Kim IS;Kumar H;Kim BW;Choi DK
神经突缺失是神经元损伤的主要特征之一。除了神经保护之外，受损脑中丢失的神经元网络的重组对于恢复正常生理功能是必要的。脑中内源性分子（如神经生长因子）的神经突生成活性被充分记载并得到科学研究的支持，科学研究显示无数化合物具有来自天然来源的神经突生长活性。由于受损的大脑缺乏重建能力，更多的研究工作集中在鉴定促进神经网络重建的化合物上。自然资源的概述沿着与相应的活动配置文件显示出有前途的结果在神经科学领域。最近，重要性也被放在了解神经突起的形成与神经元损伤的天然产物。已经发现具有丰富活性成分的天然草药产品阵列增强神经突生长。它们与神经营养因子协同作用以促进患病脑中的神经突发生。因此，使用天然产物进行神经再生为治疗神经元损伤的药物开发提供了新的见解。在这项研究中，从天然来源的各种化合物与潜在的神经突生长活性的实验模型进行了审查。
Neurite loss is one of the cardinal features of neuronal injury. Apart from neuroprotection, reorganization of the lost neuronal network in the injured brain is necessary for the restoration of normal physiological functions. Neuritogenic activity of endogenous molecules in the brain such as nerve growth factor is well documented and supported by scientific studies which show innumerable compounds having neurite outgrowth activity from natural sources. Since the damaged brain lacks the reconstructive capacity, more efforts in research are focused on the identification of compounds that promote the reformation of neuronal networks. An abundancy of natural resources along with the corresponding activity profiles have shown promising results in the field of neuroscience. Recently, importance has also been placed on understanding neurite formation by natural products in relation to neuronal injury. Arrays of natural herbal products having plentiful active constituents have been found to enhance neurite outgrowth. They act synergistically with neurotrophic factors to promote neuritogenesis in the diseased brain. Therefore use of natural products for neuroregeneration provides new insights in drug development for treating neuronal injury. In this study, various compounds from natural sources with potential neurite outgrowth activity are reviewed in experimental models.
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影响因子：
4.2
作者：
Chan, Wing-Sai;Durairajan, Siva Sundara Kumar;Li, Min
通讯作者：
Li, Min
影响因子：
3.5
作者：
Cheung, WMW;Hui, WS;Ip, NY
通讯作者：
Ip, NY
影响因子：
2.2
作者：
Chen, Zheng-ai;Wang, Jun-Long;Bian, Guang-Xing
通讯作者：
Bian, Guang-Xing
DOI：
10.1016/s0165-3806(99)00080-2
发表时间：
1999-08-05
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Cheon, EW;Saito, T
通讯作者：
Saito, T
影响因子：
2.5
作者：
Cao H;Ren M;Guo L;Shang H;Zhang J;Song Y;Wang H;Wang B;Li X;Hu J;Wang X;Wang D;Chen J;Li S;Chen L
通讯作者：
Chen L