Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1.
Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1.
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T 细胞生长因子基因：位于人类染色体 4q 和猫染色体 B1 上。
作者：
L. Seigel;M. Harper;F. Wong;R. Gallo;W. Nash;S. O’Brien
T细胞生长因子（TCGF）或白细胞介素-2（IL-2）是一种免疫调节性淋巴因子，由凝集素或抗原激活的成熟T淋巴细胞产生，并以组成性方式由某些T细胞淋巴瘤细胞系产生。通过人TCGF的分子克隆和从一组体细胞杂种（啮齿动物细胞X正常人淋巴细胞）中提取的DNA，在人4号染色体上鉴定了TCGF结构基因。原位杂交的TCGF克隆到人类染色体的显着标记的中间部分的长臂的4号染色体，表明TCGF基因位于带q26-28。用相同的分子克隆检查了用HUT-102 B2细胞制备的一组杂交体的基因组DNA。在这个产生人类T细胞白血病病毒的克隆细胞中，TCGF基因也位于4号染色体上，显然没有重排。利用分离猫染色体的体细胞杂交板，将家猫的同源TCGF基因定位在B1染色体上。连锁研究以及高分辨率G-胰蛋白酶显带表明，这猫染色体是部分同源的人类4号染色体。
T-cell growth factor (TCGF) or interleukin-2 (IL-2), an immunoregulatory lymphokine, is produced by lectin- or antigen-activated mature T lymphocytes and in a constitutive manner by certain T-cell lymphoma cell lines. By means of a molecular clone of human TCGF and DNA extracted from a panel of somatic cell hybrids (rodent cells X normal human lymphocytes), the TCGF structural gene was identified on human chromosome 4. In situ hybridization of the TCGF clone to human chromosomes resulted in significant labeling of the midportion of the long arm of chromosome 4, indicating that the TCGF gene was located at band q26-28. Genomic DNA from a panel of hybrids prepared with HUT-102 B2 cells was examined with the same molecular clone. In this clone of cells, which produces human T-cell leukemia virus, the TCGF gene was also located on chromosome 4 and was apparently not rearranged. The homologous TCGF locus in the domestic cat was assigned to chromosome B1 by using a somatic cell hybrid panel that segregates cat chromosomes. Linkage studies as well as high-resolution G-trypsin banding indicate that this feline chromosome is partially homologous to human chromosome 4.
影响因子：
56.9
作者：
DOOLITTLE, RF;HUNKAPILLER, MW;ANTONIADES, HN
通讯作者：
ANTONIADES, HN
白细胞和成纤维细胞干扰素基因位于人类第9号染色体上。
DOI：
10.1073/pnas.78.5.3123
发表时间：
1981
影响因子：
11.1
作者：
Owerbach,D;Rutter,WJ;Shows,TB;Gray,P;Goeddel,DV;Lawn,RM
通讯作者：
Lawn,RM
猿肉瘤病毒 onc 基因的人类同源物 (c-sis) 的染色体定位。
DOI：
10.1126/science.6291150
发表时间：
1982
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dalla-Favera,R;Gallo,RC;Giallongo,A;Croce,CM
通讯作者：
Croce,CM