Hyperprolactinemia Associated with Attentional Processing and Interference Control Impairments in Patients with Prolactinomas.
Hyperprolactinemia Associated with Attentional Processing and Interference Control Impairments in Patients with Prolactinomas.
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DOI：
10.3390/brainsci12081091
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发表时间：
2022-08-17
期刊：
影响因子：
3.3
通讯作者：
Song, Jian
中科院分区：
文献类型：
--
作者：
Chen, Aobo;Cao, Chenglong;Liu, Bangxin;Wang, Shuochen;Wu, Shukai;Xu, Guozheng;Song, Jian
垂体腺瘤的认知功能损害越来越受到人们的关注。高催乳素血症和肿瘤占位效应是可能的原因。本研究的目的是确定可能的认知功能障碍，并进一步探讨这些指标和催乳素（PRL）水平之间的相关性，基于控制肿瘤大小。27例泌乳素腺瘤患者（患者组）和26例健康对照组（HC组）入选本研究。所有参与者进行侧翼任务，而我们不断记录脑电图数据。在行为表现水平上，患者在两种侧翼类型中都表现出明显较慢的反应时间（RT）。在事件相关电位水平上，与HC组相比，患者引起的P2波幅降低，N2波幅增强，表明注意加工（P2）和冲突监控（N2）受损。此外，患者组也诱导较低的P3波幅相对于HC组在两种类型，表明有缺陷的注意资源分配能力。我们还发现，P3振幅和不一致的条件RT之间的显着相关性，以及随后的PRL水平的患者组。总之，这是一项创新性研究，揭示了泌乳素瘤患者的认知能力受损，并提出了过度分泌PRL水平可能的认知毒性，为进一步研究PA的认知下降提供了证据。
The cognitive impairment of pituitary adenomas (PAs) has received increasing attention. Hyperprolactinemia and tumor mass effect are the potential causes. The aim of this study was to identify possible cognitive impairment and to further explore the correlation between these indices and prolactin (PRL) levels, based on the control of tumor size. Twenty-seven patients with prolactinomas (patient group) and twenty-six matched health control group (HC group) were enrolled in this study. All participants performed the flanker task while we continuously recorded electroencephalography data. On the behavioral performance level, patients showed a significantly slower reaction time (RT) in both flanker types. Concerning the event-related potentials level, patients elicited reduced P2 and enhanced N2 amplitudes compared with the HC group, suggesting an impairment of attentional processing (P2) and conflict monitoring (N2). Moreover, the patient group also induced lower P3 amplitudes relative to the HC group in both types, indicating that there were deficits in attentional resource allocation ability. We also found a significant correlation between the P3 amplitudes and incongruent condition RTs, as well as the subsequent PRL levels in the patient group. In conclusion, this is an innovative study that reveals the impaired cognition abilities in prolactinomas, and also proposes the possible cognitive toxicity of oversecreted PRL levels, which provides evidence for further research on the cognitive decline in PAs.
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