Improvement in Attention Processing After Surgical Treatment in Functional Pituitary Adenomas: Evidence From ERP Study.
Improvement in Attention Processing After Surgical Treatment in Functional Pituitary Adenomas: Evidence From ERP Study.
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功能性垂体腺瘤手术治疗后注意力处理的改善：来自 ERP 研究的证据
DOI：
10.3389/fneur.2021.656255
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发表时间：
2021
影响因子：
3.4
通讯作者：
Song J
中科院分区：
文献类型：
--
作者：
Cao C;Huang Y;Chen A;Xu G;Song J
垂体腺瘤患者的认知能力受损。然而，关于经蝶腺瘤切除术前患者注意加工障碍和术后注意加工恢复的研究尚缺乏。本研究旨在探讨垂体腺瘤患者治疗前后与注意加工相关的电生理变化。招募了25名术前垂体患者和25名术后随访患者。27名健康对照（HC）与患者的年龄，性别和教育程度相匹配。采用事件相关电位研究术前、术后患者和HC的注意加工。在三组中，所有的情绪刺激都诱发了P200成分。术前患者P200波幅高于HC或术后患者。术后患者P200波幅降低，与HC相似。术后患者的注意加工能力较术前有所提高，但与对照组相比差异无统计学意义。异常的激素水平可能与损害注意力处理的因素有关。与HC和术后患者相比，术前患者负性刺激诱发的P200成分更高，这可能说明注意力受损后的代偿活动。此外，这些数据表明，注意力处理的改善可能归因于内分泌失调的改善。本研究表明P200成分可用于诊断术前垂体腺瘤患者的注意加工，并证明术后患者注意加工的改善。
Cognitive abilities are impaired in patients with pituitary adenoma. However, studies on attention processing impairment in preoperative patients and attention processing recovery after transsphenoidal adenomectomy are lacking. The study aims to identify the electrophysiological change that relates to attention processing in pituitary patients before and after treatment. Twenty five preoperative pituitary patients and 25 follow-up postoperative patients were recruited. 27 healthy controls (HCs) were matched to the patients with age, gender, and education. Event-related potentials were used to investigate the attention processing in the preoperative patients, postoperative patients, and HCs. Across three groups, all emotional stimuli evoked P200 components. Compared with the HCs or postoperative patients, the amplitudes of P200 in the preoperative patients were higher. Moreover, The amplitudes of P200 decreased in the postoperative patients, which were similar to that in the HCs. The attention processing was improved after surgery, but no significant differences were detected between the postoperative patients and HCs. Abnormal hormone levels may be relevant to the factor that impair attention processing. Compared with that of the HCs and postoperative patients, the P200 component elicited by negative stimuli is higher in preoperative patients, which may illustrate compensatory activity after attention impairments. Furthermore, these data indicate that improvements in attention processing may be attributed to the amelioration of endocrine disorders. This study shows that the P200 component may be used to diagnose attention processing in preoperative pituitary patients and prove the improvement of attention processing in postoperative patients.
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